Dose Calibration

Calibration refers broadly to the determination of a variable on the basis of measurement(s) on another variable . In the dose calibration problem, is the unknown level (concentration, dose) of antigen (enzyme, hormone, protein, compound) in a biological test sample to be determined from . It may be infeasible to determine directly from the specimen, but the specimen may be subjected to an assay procedure that yields an associated measurement . Given an understanding of the relationship between and , may be estimated. Such calibration is commonplace in environmental health studies. Toxicokinetic modeling for estimation of internal doses and validation of mechanistic hypotheses is a popular approach in characterizing the health effects of environmental exposures; underlying such studies is the need for precise calibration of levels of exposure agents and their metabolites from blood or other samples.

Duke Scholars

Author Marie Davidian Biostatistics & Bioinformatics, Division of Biostatistics