Skip to main content

Selection of Optimal Adjuvant Chemotherapy Regimens for Human Epidermal Growth Factor Receptor 2 (HER2) -Negative and Adjuvant Targeted Therapy for HER2-Positive Breast Cancers: An American Society of Clinical Oncology Guideline Adaptation of the Cancer Care Ontario Clinical Practice Guideline.

Publication ,  Journal Article
Denduluri, N; Somerfield, MR; Eisen, A; Holloway, JN; Hurria, A; King, TA; Lyman, GH; Partridge, AH; Telli, ML; Trudeau, ME; Wolff, AC
Published in: J Clin Oncol
July 10, 2016

PURPOSE: A Cancer Care Ontario (CCO) guideline on the selection of optimal adjuvant chemotherapy regimens for early breast cancer including adjuvant targeted therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancers was identified for adaptation. METHODS: The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for adapting clinical practice guidelines developed by other organizations. The CCO guideline was reviewed for developmental rigor and content applicability. RESULTS: On the basis of the content review of the CCO guideline, the ASCO Panel agreed that, in general, the recommendations were clear and thorough and were based on the most relevant scientific evidence, and they presented options that will be acceptable to patients. However, for some topics addressed in the CCO guideline, the ASCO Panel formulated a set of adapted recommendations on the basis of local context and practice beliefs of the Panel members. RECOMMENDATIONS: Decisions regarding adjuvant chemotherapy regimens should take into account baseline recurrence risk, toxicities, likelihood of benefit, and host factors such as comorbidities. In high-risk HER2-negative populations with excellent performance status, anthracycline- and taxane-containing regimens are the standard of care. Docetaxel and cyclophosphamide for four cycles is an acceptable non-anthracycline regimen. In high-risk HER2-positive disease, sequential anthracycline and taxanes administered concurrently with trastuzumab or docetaxel, carboplatin, and trastuzumab for six cycles are recommended. An alternative regimen in a lower-risk, node-negative, HER2-positive population is paclitaxel and trastuzumab once per week for 12 cycles. Trastuzumab should be given for 1 year. Platinum salts should not be routinely administered in the adjuvant triple-negative population until survival efficacy data become available.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 10, 2016

Volume

34

Issue

20

Start / End Page

2416 / 2427

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Combined Chemotherapy Protocols
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Denduluri, Neelima, Mark R. Somerfield, Andrea Eisen, Jamie N. Holloway, Arti Hurria, Tari A. King, Gary H. Lyman, et al. “Selection of Optimal Adjuvant Chemotherapy Regimens for Human Epidermal Growth Factor Receptor 2 (HER2) -Negative and Adjuvant Targeted Therapy for HER2-Positive Breast Cancers: An American Society of Clinical Oncology Guideline Adaptation of the Cancer Care Ontario Clinical Practice Guideline.J Clin Oncol 34, no. 20 (July 10, 2016): 2416–27. https://doi.org/10.1200/JCO.2016.67.0182.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 10, 2016

Volume

34

Issue

20

Start / End Page

2416 / 2427

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Combined Chemotherapy Protocols
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis