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Association of glutaminase expression with immune-suppressive tumor microenvironment, clinicopathologic features, and clinical outcomes in endometrial cancer.

Publication ,  Journal Article
Asaka, S; Verma, N; Yen, T-T; Hicks, JL; Nonogaki, H; Shen, Y-A; Hong, J; Asaka, R; DeMarzo, AM; Wang, T-L; Shih, I-M; Gaillard, S
Published in: Int J Gynecol Cancer
November 4, 2024

OBJECTIVE: Increased glutamine metabolism by cancer cells via upregulation of the drug-targetable enzyme glutaminase may contribute to an immune-suppressive tumor microenvironment. Inhibiting glutamine metabolism can not only suppress tumor growth, but also enhance tumor-specific immunity. We investigated the relationship between glutaminase expression, the immune tumor microenvironment, and clinicopathologic features in endometrial cancer. METHODS: Tissue microarrays constructed from 87 primary endometrial cancer specimens were stained by immunohistochemistry for glutaminase, c-Myc, mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MSH6), postmeiotic segregation increased 2 (PMS2), estrogen receptor (ER), progresterone receptor (PR), CD8, FoxP3, CD68, programmed cell death protein 1 (PD-1), and programmed cell death ligand 1 (PD-L1). We compared the immune tumor microenvironment and clinicopathologic features between glutaminase-high (H-score≥median) versus glutaminase-low (H-score

Duke Scholars

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

November 4, 2024

Volume

34

Issue

11

Start / End Page

1737 / 1744

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Tissue Array Analysis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Glutaminase
  • Female
  • Endometrial Neoplasms
  • Aged
  • Adult
 

Citation

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MLA
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Asaka, S., Verma, N., Yen, T.-T., Hicks, J. L., Nonogaki, H., Shen, Y.-A., … Gaillard, S. (2024). Association of glutaminase expression with immune-suppressive tumor microenvironment, clinicopathologic features, and clinical outcomes in endometrial cancer. Int J Gynecol Cancer, 34(11), 1737–1744. https://doi.org/10.1136/ijgc-2024-005920
Journal cover image

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

November 4, 2024

Volume

34

Issue

11

Start / End Page

1737 / 1744

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Tissue Array Analysis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Glutaminase
  • Female
  • Endometrial Neoplasms
  • Aged
  • Adult