c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality.
Publication
, Journal Article
Khan, M; Koch, WJ
Published in: Circ Res
March 4, 2016
One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit+ cardiac stem cells in the heart and their contribution towards cardiac homeostasis. A recent study reports that a subpopulation of c-kit+ cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC derived c-kit+ cells to cardiac myocyte development is regulated by bone morphogenetic protein (BMP). However, ex vivo manipulation of CNCc-kit cells reveals efficient transformation to early cardiac progenitors.
Duke Scholars
Published In
Circ Res
DOI
EISSN
1524-4571
Publication Date
March 4, 2016
Volume
118
Issue
5
Start / End Page
783 / 785
Location
United States
Related Subject Headings
- Stem Cells
- Proto-Oncogene Proteins c-kit
- Neural Crest
- Myocytes, Cardiac
- Cardiovascular System & Hematology
- Animals
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Khan, M., & Koch, W. J. (2016). c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. Circ Res, 118(5), 783–785. https://doi.org/10.1161/CIRCRESAHA.115.308103
Khan, Mohsin, and Walter J. Koch. “c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality.” Circ Res 118, no. 5 (March 4, 2016): 783–85. https://doi.org/10.1161/CIRCRESAHA.115.308103.
Khan M, Koch WJ. c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. Circ Res. 2016 Mar 4;118(5):783–5.
Khan, Mohsin, and Walter J. Koch. “c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality.” Circ Res, vol. 118, no. 5, Mar. 2016, pp. 783–85. Pubmed, doi:10.1161/CIRCRESAHA.115.308103.
Khan M, Koch WJ. c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. Circ Res. 2016 Mar 4;118(5):783–785.
Published In
Circ Res
DOI
EISSN
1524-4571
Publication Date
March 4, 2016
Volume
118
Issue
5
Start / End Page
783 / 785
Location
United States
Related Subject Headings
- Stem Cells
- Proto-Oncogene Proteins c-kit
- Neural Crest
- Myocytes, Cardiac
- Cardiovascular System & Hematology
- Animals
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology