Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice.
Publication
, Journal Article
Ervik, K; Li, Y-Z; Ji, R-R; Serhan, CN; Hansen, TV
Published in: Org Biomol Chem
December 4, 2024
The synthesis and biological evaluation of 17(R/S)-Me-RvD5n-3 DPA, an analog of the specialized pro-resolving mediators RvD5 and RvD5n-3 DPA, are presented. The synthesis was successfully accomplished utilizing Midland Alpine borane reduction, Sonogashira cross-coupling and a one-pot hydrozirconation/iodination protocol. In vivo evaluation of RvD5, RvD5n-3 DPA and 17(R/S)-Me-RvD5n-3 DPA in a mouse model of fracture revealed that all three compounds inhibited postoperative pain in male mice, but not in female mice.
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Published In
Org Biomol Chem
DOI
EISSN
1477-0539
Publication Date
December 4, 2024
Volume
22
Issue
47
Start / End Page
9266 / 9270
Location
England
Related Subject Headings
- Pain, Postoperative
- Organic Chemistry
- Molecular Structure
- Mice
- Male
- Female
- Esters
- Animals
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
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Ervik, K., Li, Y.-Z., Ji, R.-R., Serhan, C. N., & Hansen, T. V. (2024). Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice. Org Biomol Chem, 22(47), 9266–9270. https://doi.org/10.1039/d4ob01534g
Ervik, Karina, Yi-Ze Li, Ru-Rong Ji, Charles N. Serhan, and Trond V. Hansen. “Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice.” Org Biomol Chem 22, no. 47 (December 4, 2024): 9266–70. https://doi.org/10.1039/d4ob01534g.
Ervik K, Li Y-Z, Ji R-R, Serhan CN, Hansen TV. Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice. Org Biomol Chem. 2024 Dec 4;22(47):9266–70.
Ervik, Karina, et al. “Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice.” Org Biomol Chem, vol. 22, no. 47, Dec. 2024, pp. 9266–70. Pubmed, doi:10.1039/d4ob01534g.
Ervik K, Li Y-Z, Ji R-R, Serhan CN, Hansen TV. Synthesis of the methyl ester of 17(R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice. Org Biomol Chem. 2024 Dec 4;22(47):9266–9270.
Published In
Org Biomol Chem
DOI
EISSN
1477-0539
Publication Date
December 4, 2024
Volume
22
Issue
47
Start / End Page
9266 / 9270
Location
England
Related Subject Headings
- Pain, Postoperative
- Organic Chemistry
- Molecular Structure
- Mice
- Male
- Female
- Esters
- Animals
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry