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Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure.

Publication ,  Journal Article
Wang, X; Ge, Y; Lin, Y; Craig, EA; Chen, R; Miller, RK; Barrett, ES; Thurston, SW; O'Connor, TG; Rich, DQ; Zhang, JJ
Published in: Environmental science. Processes & impacts
January 2025

Urinary hydroxylated-polycyclic aromatic hydrocarbons (PAHs), with half-life less than 2 days, are established biomarkers of short-term exposure to PAHs, a ubiquitous constituent of air pollution mixture. In this study, we explore the use of PAHs-hemoglobin adducts as biomarkers of longer-term exposure to air pollution by leveraging an extant resource of blood samples collected from 235 pregnant women residing in Rochester, NY. We measured red blood cells for benzo[a]pyrene-tetrols (BaPT) and phenanthrene-tetrols (PHET), both of which are hydrolysis products of PAH-hemoglobin adduct. We utilized previously estimated PM2.5 and NO2 concentrations within the 1 km2 grid surrounding each participant's residence, calculated for up to 20 weeks before the blood collection date. Associations between PAHs tetrols and cumulative exposures to ambient PM2.5 or NO2 over different time periods were examined using a linear mixed-effects model with participant-specific random intercepts adjusting for season, gestation age, maternal age, maternal income level, and pre-pregnancy BMI. We observed positive associations between PHET concentration and cumulative PM2.5 exposure over gestational weeks 12-17, and between BaPT concentration and cumulative PM2.5 exposure over gestational weeks 3-16 prior to sample collection. Each interquartile range (IQR) increase in 14 week PM2.5 exposure (1.26 μg m-3) was associated with a 9.02% (95% CI: 0.30%, 17.7%) increase in PHET and a 12.8% (95% CI: 1.09%, 23.5%) increase in BaPT levels. In contrast, no associations were observed between either biomarker and cumulative NO2 exposures. These findings underscore the potential of PAH-hemoglobin adducts as longer-term (weeks to 4 months) exposure biomarkers of ambient PM2.5.

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Published In

Environmental science. Processes & impacts

DOI

EISSN

2050-7895

ISSN

2050-7887

Publication Date

January 2025

Volume

27

Issue

1

Start / End Page

146 / 153

Related Subject Headings

  • Pregnancy
  • Phenanthrenes
  • Particulate Matter
  • Humans
  • Hemoglobins
  • Female
  • Environmental Monitoring
  • Environmental Exposure
  • Biomarkers
  • Benzo(a)pyrene
 

Citation

APA
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Wang, X., Ge, Y., Lin, Y., Craig, E. A., Chen, R., Miller, R. K., … Zhang, J. J. (2025). Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure. Environmental Science. Processes & Impacts, 27(1), 146–153. https://doi.org/10.1039/d4em00551a
Wang, Xiangtian, Yihui Ge, Yan Lin, Emily A. Craig, Ruoxue Chen, Richard K. Miller, Emily S. Barrett, et al. “Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure.Environmental Science. Processes & Impacts 27, no. 1 (January 2025): 146–53. https://doi.org/10.1039/d4em00551a.
Wang X, Ge Y, Lin Y, Craig EA, Chen R, Miller RK, et al. Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure. Environmental science Processes & impacts. 2025 Jan;27(1):146–53.
Wang, Xiangtian, et al. “Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure.Environmental Science. Processes & Impacts, vol. 27, no. 1, Jan. 2025, pp. 146–53. Epmc, doi:10.1039/d4em00551a.
Wang X, Ge Y, Lin Y, Craig EA, Chen R, Miller RK, Barrett ES, Thurston SW, O’Connor TG, Rich DQ, Zhang JJ. Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure. Environmental science Processes & impacts. 2025 Jan;27(1):146–153.
Journal cover image

Published In

Environmental science. Processes & impacts

DOI

EISSN

2050-7895

ISSN

2050-7887

Publication Date

January 2025

Volume

27

Issue

1

Start / End Page

146 / 153

Related Subject Headings

  • Pregnancy
  • Phenanthrenes
  • Particulate Matter
  • Humans
  • Hemoglobins
  • Female
  • Environmental Monitoring
  • Environmental Exposure
  • Biomarkers
  • Benzo(a)pyrene