Anti-HIV diterpenoids from Daphne pseudomezereum.

The plants of the genus Daphne (Thymelaeaceae) are known to be sources of anti-HIV diterpenoids. Therefore, the present study focused on investigating the anti-HIV diterpenoids in Daphne pseudomezereum, for which the isolation of diterpenoids has not been previously reported. The results showed that three previously undescribed daphnane diterpenoids, onishibarins A-C (1-3), along with seven known compounds (4-10) were isolated from the fruits of Daphne pseudomezereum. Their structures were established by comprehensive analysis of physicochemical and spectroscopic data. Evaluation of the anti-HIV activity and cytotoxicity of the isolated compounds showed that compounds 1, 9, and 10 exhibited potent anti-HIV activity at EC50 = 1.26, 0.84, and 0.78 nM, respectively, with cytotoxicity at IC50 > 5 μM.

Duke Scholars

Author Chin-Ho Chen Surgery, Surgical Sciences