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Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study.

Publication ,  Journal Article
Liao, J; Yan, W; Zhang, Y; Berhane, K; Chen, W; Yang, Z; Qiu, C; Ge, Y; Bai, Z; Han, B; Xu, J; Jiang, Y-H; Gilliland, FD; Zhang, JJ; Huang, G; Chen, Z
Published in: Environmental research
December 2024

Gestational air pollution exposure was associated with childhood obesity. However, little is known about the effect of air pollution exposure during the preconception period, a critical window when environmental exposures may affect body growth trajectory and increase obesity risk. We conducted a population-based prospective cohort study of preconception women and their newborn children followed until 2 years old from metropolitan Shanghai, China to investigate the impact of preconception air pollution on childhood weight and body mass index (BMI) growth trajectories. Exposures to PM2.5, PM10, and NO2 during 3 months before conception and each trimester of pregnancy were estimated using high-resolution spatiotemporal models matched at residential addresses. Children's weight and BMI were assessed postnatally every three months. Multivariate and longitudinal models with piecewise linear mixed effects were used to examine the relationship between preconception air pollution and child growth trajectories of weight, BMI, and standardized BMI (BMIZ). The study population comprised 26,714 women in the baseline enrolled in preconception clinics and 5,834 children reached 2 years included in the analysis with 34,398 longitudinal weight and height measurements. One interquartile range (IQR) increase in preconception PM2.5 (16.2 μg/m3) was associated with a 0.078 (95% confidence interval (CI): 0.002-0.154, p = 0.04) increase in attained BMIZ and 1 IQR increase of PM10 (21.1 μg/m3) were associated with an 0.093 (95% CI: 0.002-0.184, p = 0.04) kg/m2 increase in attained BMI, respectively, at the age of two years, after controlling for individual covariates and gestational air pollution exposure. Higher weight, BMI, and BMIZ growth rates during 6-24 months of life were also associated with higher preconception NO2 and PM exposure. Males and children born to mothers less than 35 years old or with overweight/obesity status were more affected by preconception air pollution exposure on weight growth. The 3-month preconception period was a critical time window for air pollution exposure.

Duke Scholars

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Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

December 2024

Volume

267

Start / End Page

120665

Related Subject Headings

  • Toxicology
  • 41 Environmental sciences
  • 34 Chemical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 05 Environmental Sciences
  • 03 Chemical Sciences
 

Citation

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Liao, J., Yan, W., Zhang, Y., Berhane, K., Chen, W., Yang, Z., … Chen, Z. (2024). Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study. Environmental Research, 267, 120665. https://doi.org/10.1016/j.envres.2024.120665
Liao, Jiawen, Weili Yan, Yi Zhang, Kiros Berhane, Wu Chen, Zhenchun Yang, Chenyu Qiu, et al. “Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study.Environmental Research 267 (December 2024): 120665. https://doi.org/10.1016/j.envres.2024.120665.
Liao J, Yan W, Zhang Y, Berhane K, Chen W, Yang Z, et al. Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study. Environmental research. 2024 Dec;267:120665.
Liao, Jiawen, et al. “Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study.Environmental Research, vol. 267, Dec. 2024, p. 120665. Epmc, doi:10.1016/j.envres.2024.120665.
Liao J, Yan W, Zhang Y, Berhane K, Chen W, Yang Z, Qiu C, Ge Y, Bai Z, Han B, Xu J, Jiang Y-H, Gilliland FD, Zhang JJ, Huang G, Chen Z. Associations of preconception air pollution exposure with growth trajectory in young children: A prospective cohort study. Environmental research. 2024 Dec;267:120665.
Journal cover image

Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

December 2024

Volume

267

Start / End Page

120665

Related Subject Headings

  • Toxicology
  • 41 Environmental sciences
  • 34 Chemical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 05 Environmental Sciences
  • 03 Chemical Sciences