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Comorbid conditions and survival among Black women with ovarian cancer.

Publication ,  Journal Article
Richards, AR; Johnson, CE; Montalvo, NR; Alberg, AJ; Bandera, EV; Bondy, M; Collin, LJ; Cote, ML; Hastert, TA; Haller, K; Khanna, N; Marks, JR ...
Published in: Cancer
January 1, 2025

BACKGROUND: Black women with epithelial ovarian cancer (EOC) have worse survival and a higher burden of comorbid conditions compared with other racial groups. This study examines the association of comorbid conditions and medication use for these conditions with survival among Black women with EOC. METHODS: In a prospective study of 592 Black women with EOC, the Charlson comorbidity index (CCI) based on self-reported data, three cardiometabolic comorbidities (type 2 diabetes, hypertension, and hyperlipidemia), and medication use for each cardiometabolic comorbidity were evaluated. Cox proportional hazards regression models were used to examine the association of comorbid conditions and related medication use with all-cause mortality while adjusting for relevant covariates overall and by histotype (high-grade serous [HGS]/carcinosarcoma vs. non-HGS/carcinosarcoma) and stage (I/II vs. III/IV). RESULTS: A CCI of ≥2 was observed in 42% of the cohort, and 21%, 67%, and 34% of women had a history of type 2 diabetes, hypertension, and hyperlipidemia, respectively. After adjusting for prognostic factors, a CCI ≥2 (vs. 0; hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.04-1.71) and type 2 diabetes (HR, 1.42; 95% CI, 1.10-1.84) were associated with an increased risk of mortality. The increased risk of mortality for type 2 diabetes was present specifically among women with HGS/carcinosarcoma (HR, 1.47; 95% CI, 1.10-1.97) and among women with stage III/IV disease (HR, 1.47; 95% CI, 1.10-1.98). The authors did not find evidence that hypertension, hyperlipidemia, or medication use for the cardiometabolic comorbidities meaningfully impacted survival. CONCLUSION: Comorbid conditions, especially type 2 diabetes, had a significant adverse impact on survival among Black women with EOC.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 1, 2025

Volume

131

Issue

1

Start / End Page

e35694

Location

United States

Related Subject Headings

  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Hypertension
  • Hyperlipidemias
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Richards, A. R., Johnson, C. E., Montalvo, N. R., Alberg, A. J., Bandera, E. V., Bondy, M., … Peres, L. C. (2025). Comorbid conditions and survival among Black women with ovarian cancer. Cancer, 131(1), e35694. https://doi.org/10.1002/cncr.35694
Richards, Alicia R., Courtney E. Johnson, Nachalie Ramos Montalvo, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Lindsay J. Collin, et al. “Comorbid conditions and survival among Black women with ovarian cancer.Cancer 131, no. 1 (January 1, 2025): e35694. https://doi.org/10.1002/cncr.35694.
Richards AR, Johnson CE, Montalvo NR, Alberg AJ, Bandera EV, Bondy M, et al. Comorbid conditions and survival among Black women with ovarian cancer. Cancer. 2025 Jan 1;131(1):e35694.
Richards, Alicia R., et al. “Comorbid conditions and survival among Black women with ovarian cancer.Cancer, vol. 131, no. 1, Jan. 2025, p. e35694. Pubmed, doi:10.1002/cncr.35694.
Richards AR, Johnson CE, Montalvo NR, Alberg AJ, Bandera EV, Bondy M, Collin LJ, Cote ML, Hastert TA, Haller K, Khanna N, Marks JR, Peters ES, Qin B, Staples J, Terry PD, Lawson A, Schildkraut JM, Peres LC. Comorbid conditions and survival among Black women with ovarian cancer. Cancer. 2025 Jan 1;131(1):e35694.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 1, 2025

Volume

131

Issue

1

Start / End Page

e35694

Location

United States

Related Subject Headings

  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Hypertension
  • Hyperlipidemias
  • Humans
  • Female