Survival Outcomes of 997 Patients With Eyelid Sebaceous Carcinoma in the National Cancer Database.

OBJECTIVES: This study aimed to characterize the survival of patients with sebaceous carcinoma (SC) of the eyelids according to demographics and other variables. METHODS: Patients with SC of the eyelids from 2004 to 2017 were identified in the National Cancer Database. Demographic and clinical covariates were assessed. Univariate analysis and multivariate Cox proportional hazard models were employed for survival analysis. RESULTS: A total of 997 of 1101 patients were included. Most patients were females (57.8%), white (88.7%), and presented in their seventh to ninth decade of life (62.5%). Surgical excision (89.2%) was the primary treatment. Older patients were likely to be females, located in the Midwest United States, and were likely to present with T3/4 staging ( P < 0.01). Males were more likely to be younger ( P < 0.01), black ( P = 0.03), and located in the Southern United States ( P = 0.05). Kaplan-Meier univariate analysis demonstrated: greater 3-year overall survival (OS) for patients younger than 60 years (95.0%) compared with patients aged 60 to 79 (88.8%) and aged older than 80 years (69.7%) ( P < 0.01) and greater 3-year OS for patients with T1-2b staging (83.6%) compared with T3-4 staging (74.0%; P < 0.01). Multivariate Cox regression demonstrated males ( P < 0.01), older age ( P < 0.01), and M1+ staging ( P < 0.01) had greater risk of death as determined by hazard ratios. CONCLUSION: Patients with SC of the eyelids were female, white, and older than 70 years of age. There was a significantly greater 3-year OS for patients who were <60 years of age and who had T1-2b staging. Multivariate analysis demonstrated males, older age, and metastases portend a higher risk of death.

Duke Scholars

Author Christopher Robert Dermarkarian Ophthalmology, Comprehensive Ophthalmology