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Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter?

Publication ,  Journal Article
Yin, M; Cao, Y; Xu, X; Peng, H; Wang, Y; Long, Q
Published in: Human vaccines & immunotherapeutics
December 2025

This study aimed to investigate caregivers' administration of non-National Immunization Program (NIP) vaccines in rural China, and examine health system, individual, and social determinants. A cross-sectional survey (n = 1051) was conducted from July to October in 2022 in a rural county of Henan Province. Caregivers of children under six who came to township health centers for child vaccination were interviewed. Cross-tabulation and multivariate logistic regressions were used to examine the administration rate and associated factors. Qualitative interviews were conducted with healthcare professionals (n = 4) and caregivers (Focus Group Discussions, n = 4) to understand local policies, routine practices, and caregivers' experience with the administration of non-NIP vaccines. A framework approach was used to analyze qualitative data. Quantitative and qualitative data were integrated during the interpretation of the results. The administration rate for non-NIP vaccines remained low in rural Henan, 26.7% of children had not received any non-NIP vaccines, 43.5% had received 1-2 types, and around 30% had received 3-5 types. There were no significant differences in the administration of non-NIP vaccines between left-behind and non-left-behind children after adjusting for characteristics of children, caregivers, and households. Qualitative findings reflected that the high cost of non-NIP vaccines was a primary factor influencing caregivers' vaccination decision. Poor communication between physicians and caregivers was another significant factor, which was caused by low retention of healthcare workers, a shortage of professionals, and insufficient financial incentives for physicians. This study enriches the evidence on non-NIP vaccination among rural children, particularly for the vulnerable group of left-behind children.

Duke Scholars

Published In

Human vaccines & immunotherapeutics

DOI

EISSN

2164-554X

ISSN

2164-5515

Publication Date

December 2025

Volume

21

Issue

1

Start / End Page

2454744

Related Subject Headings

  • Vaccines
  • Vaccination
  • Rural Population
  • Male
  • Infant
  • Immunization Programs
  • Humans
  • Health Personnel
  • Female
  • Cross-Sectional Studies
 

Citation

APA
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ICMJE
MLA
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Yin, M., Cao, Y., Xu, X., Peng, H., Wang, Y., & Long, Q. (2025). Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter? Human Vaccines & Immunotherapeutics, 21(1), 2454744. https://doi.org/10.1080/21645515.2025.2454744
Yin, Miaomiao, Yuan Cao, Xiaolin Xu, Hanzhi Peng, Yu Wang, and Qian Long. “Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter?Human Vaccines & Immunotherapeutics 21, no. 1 (December 2025): 2454744. https://doi.org/10.1080/21645515.2025.2454744.
Yin M, Cao Y, Xu X, Peng H, Wang Y, Long Q. Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter? Human vaccines & immunotherapeutics. 2025 Dec;21(1):2454744.
Yin, Miaomiao, et al. “Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter?Human Vaccines & Immunotherapeutics, vol. 21, no. 1, Dec. 2025, p. 2454744. Epmc, doi:10.1080/21645515.2025.2454744.
Yin M, Cao Y, Xu X, Peng H, Wang Y, Long Q. Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter? Human vaccines & immunotherapeutics. 2025 Dec;21(1):2454744.

Published In

Human vaccines & immunotherapeutics

DOI

EISSN

2164-554X

ISSN

2164-5515

Publication Date

December 2025

Volume

21

Issue

1

Start / End Page

2454744

Related Subject Headings

  • Vaccines
  • Vaccination
  • Rural Population
  • Male
  • Infant
  • Immunization Programs
  • Humans
  • Health Personnel
  • Female
  • Cross-Sectional Studies