The lack of a biorepository during vaccine trials: A lost opportunity to understand staphylococcal immunity.

Development of a vaccine against Staphylococcus aureus has proven to be difficult, in no small measure due to our lack of understanding of the human immune response to this pathogen. Because the human immune response is distinct from other species often used for pre-clinical animal models, including non-human primates, it will be necessary to perform studies in humans to guide vaccine development. One can view the staphylococcal vaccine clinical trials as an opportunity to study human immune response to S. aureus infections, which of course provide outcome data. In order to gain maximal information from these clinical trials, biological materials should be taken during the trial. In this commentary article, we explore a mechanism for such collection.

Duke Scholars

Author Annette M Jackson Surgery, Abdominal Transplant Surgery

Author Vance Garrison Fowler Jr. Medicine, Infectious Diseases