Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
Publication
, Journal Article
Cynkowska, G; Cynkowski, T; Al-Ghananeem, AM; Guo, H; Ashton, P; Crooks, PA
Published in: Bioorg Med Chem Lett
August 1, 2005
The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the beta-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.
Duke Scholars
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
August 1, 2005
Volume
15
Issue
15
Start / End Page
3524 / 3527
Location
England
Related Subject Headings
- Timolol
- Prodrugs
- Polyethylene Glycols
- Medicinal & Biomolecular Chemistry
- Glaucoma
- Ethacrynic Acid
- Atenolol
- Adrenergic beta-Antagonists
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Cynkowska, G., Cynkowski, T., Al-Ghananeem, A. M., Guo, H., Ashton, P., & Crooks, P. A. (2005). Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorg Med Chem Lett, 15(15), 3524–3527. https://doi.org/10.1016/j.bmcl.2005.05.128
Cynkowska, Grazyna, Tadeusz Cynkowski, Abeer M. Al-Ghananeem, Hong Guo, Paul Ashton, and Peter A. Crooks. “Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.” Bioorg Med Chem Lett 15, no. 15 (August 1, 2005): 3524–27. https://doi.org/10.1016/j.bmcl.2005.05.128.
Cynkowska G, Cynkowski T, Al-Ghananeem AM, Guo H, Ashton P, Crooks PA. Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3524–7.
Cynkowska, Grazyna, et al. “Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.” Bioorg Med Chem Lett, vol. 15, no. 15, Aug. 2005, pp. 3524–27. Pubmed, doi:10.1016/j.bmcl.2005.05.128.
Cynkowska G, Cynkowski T, Al-Ghananeem AM, Guo H, Ashton P, Crooks PA. Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3524–3527.
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
August 1, 2005
Volume
15
Issue
15
Start / End Page
3524 / 3527
Location
England
Related Subject Headings
- Timolol
- Prodrugs
- Polyethylene Glycols
- Medicinal & Biomolecular Chemistry
- Glaucoma
- Ethacrynic Acid
- Atenolol
- Adrenergic beta-Antagonists
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry