Local Field Potential Circadian Patterns During Adaptive Deep Brain Stimulation (S32.007).

OBJECTIVE: Characterize circadian patterns of neural activity from basal ganglia nuclei in a naturalistic environment during adaptive deep brain stimulation (aDBS) in people with Parkinson's disease (PD). BACKGROUND: Chronic recordings of local field potentials (LFP) from basal ganglia nuclei can be utilized as a control signal for aDBS, and these recordings have revealed circadian patterns of neural activity. However, the impact of aDBS algorithms on circadian fluctuations is unknown. DESIGN/METHODS: The ADAPT-PD Trial (NCT04547712) is an international, multicenter, prospective, single-blind, randomized crossover pivotal trial of chronic aDBS in people with PD. Alpha-beta (8-30Hz) power was recorded during single threshold aDBS (ST-aDBS) and dual threshold aDBS (DT-aDBS). The median LFP power was derived for daytime (09:00-18:00) and nighttime (23:00-06:00) epochs. RESULTS: A total of 85 people with PD (age: 61.8[8.0]; sex: 61-males, disease duration: 12.4[6.6]) were enrolled in the study. The median [IQR] threshold (bits) used for ST-aDBS was 1182[563-2119] for ST-aDBS (N=72 hemispheres), 662[383-1275] for the upper threshold and 385[187-682] for the lower threshold in DT-aDBS (N=101 hemispheres). The median stimulation amplitude was 2.2 for ST-aDBS and 2.4 for DT-aDBS. Median daytime LFP power was 973[554-2032] for ST-aDBS, and 531[276-1095] for DT-aDBS. Median nighttime LFP power was 613[384-1231] for ST-aDBS, and 304[173-624] for DT-aDBS. LFP power change from day to night was -258[-660- -70] for ST-aDBS, and -178[-479- -30] for DT-aDBS. CONCLUSIONS: Alpha-beta power demonstrated circadian patterns during aDBS in people with PD. Clinical data and statistical comparisons between aDBS modes will be featured at the time of presentation. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff. Disclosure: Coralie De Hemptinne has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medtronic. The institution of Coralie De Hemptinne has received research support from Alpha Omega. Dr. Herrington has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic, Inc. Dr. Herrington has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MarvelBiome. Dr. Herrington has received personal compensation in the range of $0-$499 for serving as an Expert Witness for CRICO. The institution of Dr. Herrington has received research support from NIH/NINDS (K23NS099380). Dr. Beudel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic . Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz . Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Superness. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AcureX. Dr. Ostrem has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Larimar. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Aspen. Dr. Ostrem has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorders. The institution of Dr. Ostrem has received research support from Neuroderm. The institution of Dr. Ostrem has received research support from Boston Scientific. The institution of Dr. Ostrem has received research support from Medtronic. The institution of Dr. Ostrem has received research support from Rune. Author has nothing to discloseDr. Brito De Almeida has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Medtronic. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CNS Ratings. Dr. Ramirez Zamora has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Medtronic. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Rho Inc. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Signant Health. Dr. Ramirez Zamora has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevel therapeutics. Dr. Ramirez Zamora has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. The institution of Dr. Ramirez Zamora has received research support from Parkinsons Foundation. Dr. Fasano has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbott. Dr. Fasano has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Fasano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ipsen. Dr. Fasano has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Medtronic. Dr. Fasano has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Boston Scientific. Dr. Fasano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbott. Dr. Fasano has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. Dr. Fasano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ceregate. Dr. Fasano has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Inbrain Neuroelectronics. Dr. Fasano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Syneos Health. Dr. Fasano has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Annovis. Dr. Fasano has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for CADTH. The institution of Dr. Fasano has received research support from Boston Scientific. The institution of Dr. Fasano has received research support from Medtronic. The institution of Dr. Fasano has received research support from Abbvie. Dr. Fasano has received publishing royalties from a publication relating to health care. Dr. Hassell has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. Dr. Hassell has stock in BioNTech . The institution of Dr. Hassell has received research support from Medtronic. Dr. Mitchell has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. The institution of Dr. Mitchell has received research support from Medtronic. The institution of Dr. Mitchell has received research support from Deep Brain Innovations. The institution of Dr. Mitchell has received research support from National Institutes of Health. The institution of Dr. Mitchell has received research support from National Institute on Aging. Dr. Moro has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medtronic, Abbott, Kyowa. Dr. Moro has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. The institution of Dr. Moro has received research support from Abbott. The institution of Dr. Moro has received research support from IPSEN. The institution of Dr. Gostkowski has received research support from Medtronic. Nagaraja Sarangmat has nothing to disclose. Scott Stanslaski has received personal compensation for serving as an employee of Medtronic. Scott Stanslaski has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Medtronic. Scott Stanslaski has stock in Medtronic. Scott Stanslaski has received intellectual property interests from a discovery or technology relating to health care. Scott Stanslaski has received personal compensation in the range of $100,000-$499,999 for serving as a Engineer with Medtronic. Lisa Tonder has received personal compensation for serving as an employee of Medtronic. An immediate family member of Lisa Tonder has received personal compensation for serving as an employee of Medtronic. Ye Tan has received personal compensation for serving as an employee of Medtronic. Dr. Morelli has received personal compensation for serving as an employee of Medtronic. Rebekah Summers has received personal compensation for serving as an employee of Medtronic. Rebekah Summers has received research support from National Institute of Health. Dr. Bronte-Stewart has nothing to disclose.

Duke Scholars

Author Kyle Todd Mitchell Neurology, Movement Disorders