Encyclopedia of Neuroscience: Volumes 1-11
Landau Kleffner Syndrome
Publication
, Chapter
Mikati, MA; Kurdi, RM; Shamseddine, AN
January 1, 2009
Landau–Kleffner syndrome (LKS) is an acquired epileptic aphasia in which children 3–8years old, who already have developed normal speech, experience language regression with verbal auditory agnosia, abnormal epileptiform activity, and behavioral disturbances. Its pathophysiology involves synchronization, presumably through thalamic-related neuronal networks, of epileptiform activity in speech areas leading to marked discharge activation in sleep. There are no controlled studies of LKS therapy. Current treatment protocols usually include steroids or valproate as well as older and newer antiepileptic drugs. Emerging therapies include high-dose diazepam, intravenous gammaglobulin, and multiple subpial transection.
Duke Scholars
DOI
Publication Date
January 1, 2009
Volume
6
Start / End Page
V6-307-V6-311
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APA
Chicago
ICMJE
MLA
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Mikati, M. A., Kurdi, R. M., & Shamseddine, A. N. (2009). Landau Kleffner Syndrome. In Encyclopedia of Neuroscience: Volumes 1-11 (Vol. 6, pp. V6-307-V6-311). https://doi.org/10.1016/B978-008045046-9.01478-9
Mikati, M. A., R. M. Kurdi, and A. N. Shamseddine. “Landau Kleffner Syndrome.” In Encyclopedia of Neuroscience: Volumes 1-11, 6:V6-307-V6-311, 2009. https://doi.org/10.1016/B978-008045046-9.01478-9.
Mikati MA, Kurdi RM, Shamseddine AN. Landau Kleffner Syndrome. In: Encyclopedia of Neuroscience: Volumes 1-11. 2009. p. V6-307-V6-311.
Mikati, M. A., et al. “Landau Kleffner Syndrome.” Encyclopedia of Neuroscience: Volumes 1-11, vol. 6, 2009, pp. V6-307-V6-311. Scopus, doi:10.1016/B978-008045046-9.01478-9.
Mikati MA, Kurdi RM, Shamseddine AN. Landau Kleffner Syndrome. Encyclopedia of Neuroscience: Volumes 1-11. 2009. p. V6-307-V6-311.
DOI
Publication Date
January 1, 2009
Volume
6
Start / End Page
V6-307-V6-311