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A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock.

Publication ,  Journal Article
Naasz, H; Cantillo-Campos, S; Steinbock, K; Godfrey, AW; Gerardo, CJ
Published in: Toxicon
June 2025

We report a case of severe systemic copperhead (Agkistrodon contortrix) envenomation presenting with shock and minimal initial tissue injury. The patient required intravenous fluid resuscitation and a vasopressor infusion but improved with administration of high doses of Fab antivenom. He had resolution of his hypotension with antivenom, and his tissue injury progressed beyond his entire arm. He eventually stabilized with further antivenom and was discharged. Although A. contortrix envenomations are not typically severe, this case demonstrates that these bites can present with severe systemic clinical manifestations. Clinicians should focus on the management of the individual patient rather than determining therapy based solely on the offending species.

Duke Scholars

Published In

Toxicon

DOI

EISSN

1879-3150

Publication Date

June 2025

Volume

260

Start / End Page

108361

Location

England

Related Subject Headings

  • Toxicology
  • Snake Bites
  • Shock
  • Male
  • Humans
  • Crotalid Venoms
  • Antivenins
  • Animals
  • Agkistrodon
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Naasz, H., Cantillo-Campos, S., Steinbock, K., Godfrey, A. W., & Gerardo, C. J. (2025). A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock. Toxicon, 260, 108361. https://doi.org/10.1016/j.toxicon.2025.108361
Naasz, Hayley, Santiago Cantillo-Campos, Kyle Steinbock, Andrew W. Godfrey, and Charles J. Gerardo. “A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock.Toxicon 260 (June 2025): 108361. https://doi.org/10.1016/j.toxicon.2025.108361.
Naasz H, Cantillo-Campos S, Steinbock K, Godfrey AW, Gerardo CJ. A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock. Toxicon. 2025 Jun;260:108361.
Naasz, Hayley, et al. “A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock.Toxicon, vol. 260, June 2025, p. 108361. Pubmed, doi:10.1016/j.toxicon.2025.108361.
Naasz H, Cantillo-Campos S, Steinbock K, Godfrey AW, Gerardo CJ. A case of severe systemic copperhead (Agkistrodon contortrix) envenomation with shock. Toxicon. 2025 Jun;260:108361.
Journal cover image

Published In

Toxicon

DOI

EISSN

1879-3150

Publication Date

June 2025

Volume

260

Start / End Page

108361

Location

England

Related Subject Headings

  • Toxicology
  • Snake Bites
  • Shock
  • Male
  • Humans
  • Crotalid Venoms
  • Antivenins
  • Animals
  • Agkistrodon
  • 3214 Pharmacology and pharmaceutical sciences