Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection.
Publication
, Journal Article
Lee, T-H; Wegermann, K; Safeek, R; Mock, M; Lusk, S; John-Williams, LS; Thompson, WJ; Lucas, JE; Moseley, MA; Patel, K; Naggie, S
Published in: Metabolomics
July 1, 2025
Non-invasive assessments for advanced liver fibrosis have limited accuracy in persons with human immunodeficiency virus (HIV) (PWH) who have hepatitis C virus (HCV) co-infection, and new tools are needed. Our aim was to discover oxylipin profiles associated with advanced liver fibrosis in treatment-naïve patients with HIV/HCV co-infection. Serum samples from 40 PWH with HCV were subjected to targeted oxylipin analysis. A model with AST and seven metabolites, including 5(S)-HEPE, 8-HETE, 14,15-DiHETrE, 4-HDoHE, 14- HDoHE, 7-HDoHE, and 9,10-DiHOME yielded an area under the receiver operating characteristic curve of 0.93, with optimal sensitivity and specificity of 86% and 88%, respectively.
Duke Scholars
Published In
Metabolomics
DOI
EISSN
1573-3890
Publication Date
July 1, 2025
Volume
21
Issue
4
Start / End Page
96
Location
United States
Related Subject Headings
- Oxylipins
- Middle Aged
- Male
- Liver Cirrhosis
- Lipids
- Humans
- Hepatitis C
- Hepacivirus
- HIV Infections
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, T.-H., Wegermann, K., Safeek, R., Mock, M., Lusk, S., John-Williams, L. S., … Naggie, S. (2025). Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection. Metabolomics, 21(4), 96. https://doi.org/10.1007/s11306-025-02293-5
Lee, Tzu-Hao, Kara Wegermann, Rachel Safeek, Meredith Mock, Sam Lusk, Lisa St John-Williams, Will J. Thompson, et al. “Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection.” Metabolomics 21, no. 4 (July 1, 2025): 96. https://doi.org/10.1007/s11306-025-02293-5.
Lee T-H, Wegermann K, Safeek R, Mock M, Lusk S, John-Williams LS, et al. Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection. Metabolomics. 2025 Jul 1;21(4):96.
Lee, Tzu-Hao, et al. “Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection.” Metabolomics, vol. 21, no. 4, July 2025, p. 96. Pubmed, doi:10.1007/s11306-025-02293-5.
Lee T-H, Wegermann K, Safeek R, Mock M, Lusk S, John-Williams LS, Thompson WJ, Lucas JE, Moseley MA, Patel K, Naggie S. Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection. Metabolomics. 2025 Jul 1;21(4):96.
Published In
Metabolomics
DOI
EISSN
1573-3890
Publication Date
July 1, 2025
Volume
21
Issue
4
Start / End Page
96
Location
United States
Related Subject Headings
- Oxylipins
- Middle Aged
- Male
- Liver Cirrhosis
- Lipids
- Humans
- Hepatitis C
- Hepacivirus
- HIV Infections
- Female