<i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion.
Publication
, Journal Article
Chen, J; Scheiner, AR; Falsztyn, IB; Baugh, LR
Published in: microPublication biology
January 2025
The mammalian IRS1 gene is an important adaptor for the insulin and insulin-like growth factor receptors, but its sole homolog in the nematode C. elegans , ist-1 , has received relatively little attention. We show that ist-1 /IRS1 has modest effects on L1 starvation resistance, with two null mutants increasing larval growth and reproduction after recovery from extended L1 arrest. ist-1 /IRS1 mutants increase nuclear localization of DAF-16 /FoxO, a critical effector of insulin/IGF signaling, in starved L1 larvae, consistent with IST-1 /IRS1 transducing DAF-2 /IGFR signaling. However, epistasis analysis suggests that ist-1 /IRS1 also functions independently of daf-16 /FoxO , suggesting additional, novel function.
Duke Scholars
Published In
microPublication biology
DOI
EISSN
2578-9430
ISSN
2578-9430
Publication Date
January 2025
Volume
2025
Citation
APA
Chicago
ICMJE
MLA
NLM
Chen, J., Scheiner, A. R., Falsztyn, I. B., & Baugh, L. R. (2025). <i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion. MicroPublication Biology, 2025. https://doi.org/10.17912/micropub.biology.001648
Chen, Jingxian, Ainsley R. Scheiner, Ivan B. Falsztyn, and L Ryan Baugh. “<i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion.” MicroPublication Biology 2025 (January 2025). https://doi.org/10.17912/micropub.biology.001648.
Chen J, Scheiner AR, Falsztyn IB, Baugh LR. <i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion. microPublication biology. 2025 Jan;2025.
Chen, Jingxian, et al. “<i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion.” MicroPublication Biology, vol. 2025, Jan. 2025. Epmc, doi:10.17912/micropub.biology.001648.
Chen J, Scheiner AR, Falsztyn IB, Baugh LR. <i>ist-1/IRS1</i> affects L1 starvation resistance in <i>daf-16/FoxO-</i> dependent and independent fashion. microPublication biology. 2025 Jan;2025.
Published In
microPublication biology
DOI
EISSN
2578-9430
ISSN
2578-9430
Publication Date
January 2025
Volume
2025