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2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.

Publication ,  Journal Article
Pappas, P; Lentz, RJ; Stover, KR; Wiederhold, NP; Ardura, MI; Baddley, JW; Badreldin, N; Bahr, NC; Bloch, K; Kauffman, CA; Miller, RA; Wolf, J ...
Published in: Clin Infect Dis
January 16, 2026

This article is part of a larger clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this article, the panel provides recommendations for treatment of mild and moderate acute pulmonary histoplasmosis. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

Duke Scholars

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

January 16, 2026

Volume

81

Issue

Supplement_3

Start / End Page

i39 / i45

Location

United States

Related Subject Headings

  • Societies, Medical
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Microbiology
  • Lung Diseases, Fungal
  • Humans
  • Histoplasmosis
  • Histoplasma
  • Female
  • Child
 

Citation

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Chicago
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MLA
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Pappas, P., Lentz, R. J., Stover, K. R., Wiederhold, N. P., Ardura, M. I., Baddley, J. W., … Arnold, S. R. (2026). 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. Clin Infect Dis, 81(Supplement_3), i39–i45. https://doi.org/10.1093/cid/ciaf258
Pappas, Peter, Robert J. Lentz, Kayla R. Stover, Nathan P. Wiederhold, Monica I. Ardura, John W. Baddley, Nevert Badreldin, et al. “2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People.Clin Infect Dis 81, no. Supplement_3 (January 16, 2026): i39–45. https://doi.org/10.1093/cid/ciaf258.
Pappas P, Lentz RJ, Stover KR, Wiederhold NP, Ardura MI, Baddley JW, Badreldin N, Bahr NC, Bloch K, Kauffman CA, Miller RA, Mocherla S, Saccente M, Schwartz I, Wolf J, Loveless J, Spec A, Arnold SR. 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. Clin Infect Dis. 2026 Jan 16;81(Supplement_3):i39–i45.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

January 16, 2026

Volume

81

Issue

Supplement_3

Start / End Page

i39 / i45

Location

United States

Related Subject Headings

  • Societies, Medical
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Microbiology
  • Lung Diseases, Fungal
  • Humans
  • Histoplasmosis
  • Histoplasma
  • Female
  • Child