Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines.
Publication
, Journal Article
Maciel, M; Baden, LR; Briney, B; Doria-Rose, NA; Kiwanuka, KN; Krebs, SJ; Malaspina, A; Tomaras, GD; Ward, A; Karlsson Hedestam, GB ...
Published in: NPJ Vaccines
July 17, 2025
Advances in HIV vaccine development focus on eliciting broadly neutralizing antibodies (bNAbs) through next-generation immunogens. Human trials are testing these candidates for their ability to initiate B cell maturation. This workshop report reviews emerging data and methods for analyzing B cell repertoires, highlighting strategies to streamline these labor-intensive processes. The goal is to enable timely, cost-effective design of sequential immunization regimens that induce potent, protective bNAbs against HIV.
Duke Scholars
Published In
NPJ Vaccines
DOI
EISSN
2059-0105
Publication Date
July 17, 2025
Volume
10
Issue
1
Start / End Page
157
Location
England
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Maciel, M., Baden, L. R., Briney, B., Doria-Rose, N. A., Kiwanuka, K. N., Krebs, S. J., … D’Souza, M. P. (2025). Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines. NPJ Vaccines, 10(1), 157. https://doi.org/10.1038/s41541-025-01168-z
Maciel, Milton, Lindsey R. Baden, Brian Briney, Nicole A. Doria-Rose, Kasalina N. Kiwanuka, Shelly J. Krebs, Angela Malaspina, et al. “Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines.” NPJ Vaccines 10, no. 1 (July 17, 2025): 157. https://doi.org/10.1038/s41541-025-01168-z.
Maciel M, Baden LR, Briney B, Doria-Rose NA, Kiwanuka KN, Krebs SJ, et al. Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines. NPJ Vaccines. 2025 Jul 17;10(1):157.
Maciel, Milton, et al. “Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines.” NPJ Vaccines, vol. 10, no. 1, July 2025, p. 157. Pubmed, doi:10.1038/s41541-025-01168-z.
Maciel M, Baden LR, Briney B, Doria-Rose NA, Kiwanuka KN, Krebs SJ, Malaspina A, Tomaras GD, Ward A, Karlsson Hedestam GB, Williams WB, D’Souza MP. Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines. NPJ Vaccines. 2025 Jul 17;10(1):157.
Published In
NPJ Vaccines
DOI
EISSN
2059-0105
Publication Date
July 17, 2025
Volume
10
Issue
1
Start / End Page
157
Location
England
Related Subject Headings
- 3207 Medical microbiology
- 3204 Immunology