Association of complement allotype C4B2 with anterior uveitis.
Publication
, Journal Article
Wakefield, D; Buckley, R; Golding, J; McCluskey, P; Abi-Hanna, D; Charlesworth, J; Pussell, B
Published in: Hum Immunol
April 1988
We have studied allotypes of the fourth component of complement (C4) in 44 patients with inflammatory eye disease in order to define genetic susceptibility factors further. Twenty-six patients had uveitis (18 had anterior uveitis) and 18 patients had retinal vasculitis. There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc less than 0.002), especially in HLA B27 positive males. In contrast, there was no increased incidence of specific allotypes in patients with posterior uveitis or retinal vasculitis. This genetic association may form part of a disease susceptibility supratype in patients with anterior uveitis.
Duke Scholars
Published In
Hum Immunol
DOI
ISSN
0198-8859
Publication Date
April 1988
Volume
21
Issue
4
Start / End Page
233 / 237
Location
United States
Related Subject Headings
- Vasculitis
- Uveitis, Anterior
- Uveitis
- Retinal Diseases
- Male
- Immunology
- Humans
- Genetic Markers
- Female
- Complement C4b
Citation
APA
Chicago
ICMJE
MLA
NLM
Wakefield, D., Buckley, R., Golding, J., McCluskey, P., Abi-Hanna, D., Charlesworth, J., & Pussell, B. (1988). Association of complement allotype C4B2 with anterior uveitis. Hum Immunol, 21(4), 233–237. https://doi.org/10.1016/0198-8859(88)90032-8
Wakefield, D., R. Buckley, J. Golding, P. McCluskey, D. Abi-Hanna, J. Charlesworth, and B. Pussell. “Association of complement allotype C4B2 with anterior uveitis.” Hum Immunol 21, no. 4 (April 1988): 233–37. https://doi.org/10.1016/0198-8859(88)90032-8.
Wakefield D, Buckley R, Golding J, McCluskey P, Abi-Hanna D, Charlesworth J, et al. Association of complement allotype C4B2 with anterior uveitis. Hum Immunol. 1988 Apr;21(4):233–7.
Wakefield, D., et al. “Association of complement allotype C4B2 with anterior uveitis.” Hum Immunol, vol. 21, no. 4, Apr. 1988, pp. 233–37. Pubmed, doi:10.1016/0198-8859(88)90032-8.
Wakefield D, Buckley R, Golding J, McCluskey P, Abi-Hanna D, Charlesworth J, Pussell B. Association of complement allotype C4B2 with anterior uveitis. Hum Immunol. 1988 Apr;21(4):233–237.
Published In
Hum Immunol
DOI
ISSN
0198-8859
Publication Date
April 1988
Volume
21
Issue
4
Start / End Page
233 / 237
Location
United States
Related Subject Headings
- Vasculitis
- Uveitis, Anterior
- Uveitis
- Retinal Diseases
- Male
- Immunology
- Humans
- Genetic Markers
- Female
- Complement C4b