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Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use.

Publication ,  Journal Article
Pacek, LR; Ganz, O; Rubenstein, D; Barnwell, PV; McClernon, FJ
Published in: Nicotine Tob Res
March 24, 2026

INTRODUCTION: The aim of this study was to empirically identify subgroups of dual cigarette and electronic nicotine delivery systems (ENDS) product users based on their motivations for ENDS use. METHODS: Data came from n = 713 adult dual cigarette/ENDS users in the Population Assessment of Tobacco and Health Wave 6 public use data file. We used latent class analysis to identify qualitatively different subgroups within the sample and applied logistic regression to assess correlates of latent class membership. RESULTS: We identified two latent classes: "Substituters" (62.81%) and Complementers (37.19%). Classes were primarily distinguished by Substituters reporting a higher probability of using ENDS to cut down on (97.99%) or quit (86.12%) cigarette smoking; the converse was true for Complementers (16.95%; 3.17%, respectively). Compared to Substituters, Complementers (aOR = 0.87, 95% CI = 0.81 to 0.96) expressed less interest in smoking cessation. Moreover, Complementers were less likely to have made a past-year smoking quit attempt (aOR = 0.46, 95% CI = 0.27 to 0.77) and more likely to smoke the same number of cigarettes as usual (aOR = 3.62, 95% CI = 2.04 to 6.42) or more cigarettes than usual (aOR = 5.96, 95% CI = 1.92 to 18.51) on days when they both smoked and vaped than were Substituters. No sociodemographic differences were observed. CONCLUSIONS: We identified distinct latent classes of dual cigarette/ENDS users, predominantly differentiated based on their reported probabilities of using ENDS to assist in quitting or cutting down on cigarette smoking. Findings that class membership is associated with interest in quitting and quit attempts have significant health, treatment, and study design implications. IMPLICATIONS: The identification of distinct classes of dual cigarette/ENDS users based on their motivations for ENDS use and differential associations between class membership and tobacco use characteristics has a number of implications. Class membership may affect cessation treatment approaches and has significant implications for scientific study design.

Duke Scholars

Published In

Nicotine Tob Res

DOI

EISSN

1469-994X

Publication Date

March 24, 2026

Volume

28

Issue

4

Start / End Page

668 / 676

Location

England

Related Subject Headings

  • Young Adult
  • Vaping
  • Tobacco Products
  • Smoking Cessation
  • Public Health
  • Motivation
  • Middle Aged
  • Male
  • Latent Class Analysis
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Pacek, L. R., Ganz, O., Rubenstein, D., Barnwell, P. V., & McClernon, F. J. (2026). Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use. Nicotine Tob Res, 28(4), 668–676. https://doi.org/10.1093/ntr/ntaf188
Pacek, Lauren R., Ollie Ganz, Dana Rubenstein, Patrick V. Barnwell, and F Joseph McClernon. “Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use.Nicotine Tob Res 28, no. 4 (March 24, 2026): 668–76. https://doi.org/10.1093/ntr/ntaf188.
Pacek LR, Ganz O, Rubenstein D, Barnwell PV, McClernon FJ. Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use. Nicotine Tob Res. 2026 Mar 24;28(4):668–76.
Pacek, Lauren R., et al. “Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use.Nicotine Tob Res, vol. 28, no. 4, Mar. 2026, pp. 668–76. Pubmed, doi:10.1093/ntr/ntaf188.
Pacek LR, Ganz O, Rubenstein D, Barnwell PV, McClernon FJ. Identifying Latent Classes of Dual Cigarette/ENDS Users Based on Motivations for ENDS Use: Product Substitution Versus Complementary Use. Nicotine Tob Res. 2026 Mar 24;28(4):668–676.
Journal cover image

Published In

Nicotine Tob Res

DOI

EISSN

1469-994X

Publication Date

March 24, 2026

Volume

28

Issue

4

Start / End Page

668 / 676

Location

England

Related Subject Headings

  • Young Adult
  • Vaping
  • Tobacco Products
  • Smoking Cessation
  • Public Health
  • Motivation
  • Middle Aged
  • Male
  • Latent Class Analysis
  • Humans