Asymmetric Total Synthesis of Daucane-Type Sesquiterpenoids (+)-Ferutinin and (+)-Kuhistanicaol G.

Given the poor outcomes associated with current pancreatic cancer therapies, the "antiausterity" activity of ferutinin and kuhistanicaol G is particularly encouraging. The asymmetric syntheses of (+)-ferutinin and (+)-kuhistanicaol G are achieved through a sequence involving tandem radical addition/allylation, chelation-controlled nucleophilic addition, and Chugaev elimination. This synthetic strategy enables the efficient construction of appropriately functionalized 5,7-fused daucane skeletons. Our work paves the way for the development of new pancreatic cancer therapeutics and provides access to chemical probes for elucidating mechanisms of action.

Duke Scholars

Author Jiyong Hong Chemistry