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Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement.

Publication ,  Journal Article
Powell, CA; Winer, IS; Tarney, CM; Gaillard, S; O'Cearbhaill, RE
Published in: Gynecologic oncology
November 2025

Interstitial lung disease (ILD) is a potentially serious and sometimes fatal complication of targeted therapies, including antibody-drug conjugates and immunotherapies, in gynecologic oncology. Risk factors include pre-existing lung disease, advanced age and prior thoracic radiation. Early detection, patient and clinician education, and prompt multidisciplinary collaboration are critical to mitigate ILD morbidity and mortality. This Society of Gynecologic Oncology clinical practice statement provides evidence-based recommendations for the diagnosis, grading and management of ILD associated with gynecologic cancer therapies, emphasizing the importance of baseline risk assessment, ongoing monitoring and standardized intervention protocols to optimize patient outcomes.

Duke Scholars

Published In

Gynecologic oncology

DOI

EISSN

1095-6859

ISSN

0090-8258

Publication Date

November 2025

Volume

202

Start / End Page

137 / 145

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Lung Diseases, Interstitial
  • Humans
  • Genital Neoplasms, Female
  • Female
  • 3215 Reproductive medicine
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Powell, C. A., Winer, I. S., Tarney, C. M., Gaillard, S., & O’Cearbhaill, R. E. (2025). Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement. Gynecologic Oncology, 202, 137–145. https://doi.org/10.1016/j.ygyno.2025.09.010
Powell, Charles A., Ira S. Winer, Christopher M. Tarney, Stéphanie Gaillard, and Róisín E. O’Cearbhaill. “Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement.Gynecologic Oncology 202 (November 2025): 137–45. https://doi.org/10.1016/j.ygyno.2025.09.010.
Powell CA, Winer IS, Tarney CM, Gaillard S, O’Cearbhaill RE. Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement. Gynecologic oncology. 2025 Nov;202:137–45.
Powell, Charles A., et al. “Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement.Gynecologic Oncology, vol. 202, Nov. 2025, pp. 137–45. Epmc, doi:10.1016/j.ygyno.2025.09.010.
Powell CA, Winer IS, Tarney CM, Gaillard S, O’Cearbhaill RE. Interstitial lung disease in targeted therapies: A Society of Gynecologic Oncology clinical practice statement. Gynecologic oncology. 2025 Nov;202:137–145.
Journal cover image

Published In

Gynecologic oncology

DOI

EISSN

1095-6859

ISSN

0090-8258

Publication Date

November 2025

Volume

202

Start / End Page

137 / 145

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Lung Diseases, Interstitial
  • Humans
  • Genital Neoplasms, Female
  • Female
  • 3215 Reproductive medicine
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences