Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants.
Publication
, Journal Article
Figueroa, AL; Girard, B; Edwards, DK; Nasir, A; Johnson, K; Hack, S; Cao, X; de Windt, E; Urdaneta, V; Priddy, F; Das, R; Montefiori, DC; Chalkias, S
Published in: Open Forum Infect Dis
December 2025
In this ongoing, open-label, phase 3b/4 study, JN.1- and KP.2-encoding monovalent mRNA-1273 vaccines elicited robust neutralization of vaccine-matched variants (JN.1, KP.2) and cross-neutralized JN.1 subvariants circulating during the study (September 2024-November 2024; KP.3.1.1, XEC, LP.8.1) in vaccinated adults, showing reduced cross-neutralization against all subvariants tested. No safety concerns were identified.
Duke Scholars
Published In
Open Forum Infect Dis
DOI
ISSN
2328-8957
Publication Date
December 2025
Volume
12
Issue
12
Start / End Page
ofaf705
Location
United States
Related Subject Headings
- 3207 Medical microbiology
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Figueroa, A. L., Girard, B., Edwards, D. K., Nasir, A., Johnson, K., Hack, S., … Chalkias, S. (2025). Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants. Open Forum Infect Dis, 12(12), ofaf705. https://doi.org/10.1093/ofid/ofaf705
Figueroa, Amparo L., Bethany Girard, Darin K. Edwards, Arshan Nasir, Kimball Johnson, Steven Hack, Xin Cao, et al. “Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants.” Open Forum Infect Dis 12, no. 12 (December 2025): ofaf705. https://doi.org/10.1093/ofid/ofaf705.
Figueroa AL, Girard B, Edwards DK, Nasir A, Johnson K, Hack S, et al. Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants. Open Forum Infect Dis. 2025 Dec;12(12):ofaf705.
Figueroa, Amparo L., et al. “Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants.” Open Forum Infect Dis, vol. 12, no. 12, Dec. 2025, p. ofaf705. Pubmed, doi:10.1093/ofid/ofaf705.
Figueroa AL, Girard B, Edwards DK, Nasir A, Johnson K, Hack S, Cao X, de Windt E, Urdaneta V, Priddy F, Das R, Montefiori DC, Chalkias S. Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants. Open Forum Infect Dis. 2025 Dec;12(12):ofaf705.
Published In
Open Forum Infect Dis
DOI
ISSN
2328-8957
Publication Date
December 2025
Volume
12
Issue
12
Start / End Page
ofaf705
Location
United States
Related Subject Headings
- 3207 Medical microbiology
- 3202 Clinical sciences