GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.
Publication
, Journal Article
Ahmed, M; Burhan, M; Shafiq, A; Hashmi, TM; Ahmed, R; Fudim, M; Mentz, RJ; Fonarow, GC
Published in: Clin Cardiol
December 2025
This comprehensive meta-analysis reveals that GLP-1 and dual GLP-1/GIP receptor agonists are associated with reduced risk of composite cardiovascular endpoints and worsening heart failure events. However, no statistically significant differences were observed regarding all-cause or cardiovascular mortality.
Duke Scholars
Published In
Clin Cardiol
DOI
EISSN
1932-8737
Publication Date
December 2025
Volume
48
Issue
12
Start / End Page
e70234
Location
United States
Related Subject Headings
- Ventricular Function, Left
- Treatment Outcome
- Stroke Volume
- Receptors, Gastrointestinal Hormone
- Incretins
- Humans
- Heart Failure
- Glucagon-Like Peptide-1 Receptor Agonists
- Glucagon-Like Peptide-1 Receptor
- Glucagon-Like Peptide 1
Citation
APA
Chicago
ICMJE
MLA
NLM
Ahmed, M., Burhan, M., Shafiq, A., Hashmi, T. M., Ahmed, R., Fudim, M., … Fonarow, G. C. (2025). GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Clin Cardiol, 48(12), e70234. https://doi.org/10.1002/clc.70234
Ahmed, Mushood, Muhammad Burhan, Aimen Shafiq, Tallal Mushtaq Hashmi, Raheel Ahmed, Marat Fudim, Robert J. Mentz, and Gregg C. Fonarow. “GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.” Clin Cardiol 48, no. 12 (December 2025): e70234. https://doi.org/10.1002/clc.70234.
Ahmed M, Burhan M, Shafiq A, Hashmi TM, Ahmed R, Fudim M, et al. GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Clin Cardiol. 2025 Dec;48(12):e70234.
Ahmed, Mushood, et al. “GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.” Clin Cardiol, vol. 48, no. 12, Dec. 2025, p. e70234. Pubmed, doi:10.1002/clc.70234.
Ahmed M, Burhan M, Shafiq A, Hashmi TM, Ahmed R, Fudim M, Mentz RJ, Fonarow GC. GLP-1 and Dual GLP-1/GIP Receptor Agonists in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Clin Cardiol. 2025 Dec;48(12):e70234.
Published In
Clin Cardiol
DOI
EISSN
1932-8737
Publication Date
December 2025
Volume
48
Issue
12
Start / End Page
e70234
Location
United States
Related Subject Headings
- Ventricular Function, Left
- Treatment Outcome
- Stroke Volume
- Receptors, Gastrointestinal Hormone
- Incretins
- Humans
- Heart Failure
- Glucagon-Like Peptide-1 Receptor Agonists
- Glucagon-Like Peptide-1 Receptor
- Glucagon-Like Peptide 1