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SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload

Publication ,  Journal Article
Riley, HJ; Kelly, RR; Van Laer, AO; Neff, LS; Dasgupta, S; Baicu, CF; McDonald, LT; LaRue, AC; Zile, MR; Bradshaw, AD
Published in: American Journal of Physiology-Heart and Circulatory Physiology
February 1, 2021
Published version (DOI) Publisher Link

Myocardial fibrosis and the resultant increases in LV and myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, a murine model of cardiac fibrosis induced by PO was used to demonstrate a critical function of SPARC in bone marrow-derived cells that drives cardiac fibrosis and increases in cardiac macrophages.

Duke Scholars

Gary Michael Felker
Author Gary Michael Felker Medicine, Cardiology

Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

10.1152/ajpheart.00552.2020

EISSN

1522-1539

ISSN

0363-6135

Publication Date

February 1, 2021

Volume

320

Issue

2

Start / End Page

H604 / H612

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Riley, H. J., Kelly, R. R., Van Laer, A. O., Neff, L. S., Dasgupta, S., Baicu, C. F., … Bradshaw, A. D. (2021). SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload. American Journal of Physiology-Heart and Circulatory Physiology, 320(2), H604–H612. https://doi.org/10.1152/ajpheart.00552.2020
Riley, Hannah J., Ryan R. Kelly, An O. Van Laer, Lily S. Neff, Shaoni Dasgupta, Catalin F. Baicu, Lindsay T. McDonald, Amanda C. LaRue, Michael R. Zile, and Amy D. Bradshaw. “SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload.” American Journal of Physiology-Heart and Circulatory Physiology 320, no. 2 (February 1, 2021): H604–12. https://doi.org/10.1152/ajpheart.00552.2020.
Riley HJ, Kelly RR, Van Laer AO, Neff LS, Dasgupta S, Baicu CF, et al. SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload. American Journal of Physiology-Heart and Circulatory Physiology. 2021 Feb 1;320(2):H604–12.
Riley, Hannah J., et al. “SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 320, no. 2, American Physiological Society, Feb. 2021, pp. H604–12. Crossref, doi:10.1152/ajpheart.00552.2020.
Riley HJ, Kelly RR, Van Laer AO, Neff LS, Dasgupta S, Baicu CF, McDonald LT, LaRue AC, Zile MR, Bradshaw AD. SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload. American Journal of Physiology-Heart and Circulatory Physiology. American Physiological Society; 2021 Feb 1;320(2):H604–H612.

Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

10.1152/ajpheart.00552.2020

EISSN

1522-1539

ISSN

0363-6135

Publication Date

February 1, 2021

Volume

320

Issue

2

Start / End Page

H604 / H612

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology