Scholars@Duke

Pressure overload generates a cardiac-specific profile of inflammatory mediators

Publication ,  Journal Article
O’Brien, M; Baicu, CF; Van Laer, AO; Zhang, Y; McDonald, LT; LaRue, AC; Zile, MR; Bradshaw, AD
Published in: American Journal of Physiology-Heart and Circulatory Physiology
August 1, 2020
Published version (DOI) Publisher Link

Myocardial fibrosis and the resultant increases in myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, cytokine profiles produced in a murine model of cardiac fibrosis induced by PO were compared with those produced in response to silica-induced lung fibrosis. A unique profile of cardiac tissue-specific and plasma-derived factors generated in response to PO are reported.

Duke Scholars

Gary Michael Felker
Author Gary Michael Felker Medicine, Cardiology

Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

10.1152/ajpheart.00274.2020

EISSN

1522-1539

ISSN

0363-6135

Publication Date

August 1, 2020

Volume

319

Issue

2

Start / End Page

H331 / H340

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
O’Brien, M., Baicu, C. F., Van Laer, A. O., Zhang, Y., McDonald, L. T., LaRue, A. C., … Bradshaw, A. D. (2020). Pressure overload generates a cardiac-specific profile of inflammatory mediators. American Journal of Physiology-Heart and Circulatory Physiology, 319(2), H331–H340. https://doi.org/10.1152/ajpheart.00274.2020
O’Brien, Matthew, Catalin F. Baicu, An O. Van Laer, Yuhua Zhang, Lindsey T. McDonald, Amanda C. LaRue, Michael R. Zile, and Amy D. Bradshaw. “Pressure overload generates a cardiac-specific profile of inflammatory mediators.” American Journal of Physiology-Heart and Circulatory Physiology 319, no. 2 (August 1, 2020): H331–40. https://doi.org/10.1152/ajpheart.00274.2020.
O’Brien M, Baicu CF, Van Laer AO, Zhang Y, McDonald LT, LaRue AC, et al. Pressure overload generates a cardiac-specific profile of inflammatory mediators. American Journal of Physiology-Heart and Circulatory Physiology. 2020 Aug 1;319(2):H331–40.
O’Brien, Matthew, et al. “Pressure overload generates a cardiac-specific profile of inflammatory mediators.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 319, no. 2, American Physiological Society, Aug. 2020, pp. H331–40. Crossref, doi:10.1152/ajpheart.00274.2020.
O’Brien M, Baicu CF, Van Laer AO, Zhang Y, McDonald LT, LaRue AC, Zile MR, Bradshaw AD. Pressure overload generates a cardiac-specific profile of inflammatory mediators. American Journal of Physiology-Heart and Circulatory Physiology. American Physiological Society; 2020 Aug 1;319(2):H331–H340.

Published In

American Journal of Physiology-Heart and Circulatory Physiology

DOI

10.1152/ajpheart.00274.2020

EISSN

1522-1539

ISSN

0363-6135

Publication Date

August 1, 2020

Volume

319

Issue

2

Start / End Page

H331 / H340

Publisher

American Physiological Society

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3208 Medical physiology
  • 3201 Cardiovascular medicine and haematology
  • 1116 Medical Physiology
  • 0606 Physiology