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Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory.

Journal articles  - Journal Article
Ibemere, SO; Knisely, MR; Akpotu, I; Darby, JE; de Martelly, VA; Doorenbos, AZ; Ezenwa, MO; Matthie, NS; Molokie, RE; Schlaeger, JM; Shah, N ...
Published in: Pain Manag Nurs
August 2026

BACKGROUND: Even though there is clear evidence supporting the use of complementary and integrative health (CIH) interventions for chronic pain, their integration into clinical care is challenging. Thus, the purpose of this study was to understand how the integration of CIH interventions, namely, guided relaxation and acupuncture evaluated in the Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain (GRACE Trial), would impact clinic workflow at each study site. METHODS: We conducted a qualitative descriptive study using individual interviews with healthcare providers and staff working at GRACE Trial sites. Interview data were analyzed using modified rapid qualitative analysis. RESULTS: We interviewed 13 healthcare providers from three GRACE Trial sites. Two major themes were identified: (1) the variable impact of CIH integration on clinic operations, and (2) the introduction of CIH interventions into clinical practice. CONCLUSION: This study highlights the importance and value of participatory approaches in integrating CIH interventions into healthcare settings. This study contributes to the CIH literature by addressing chronic pain and informing the identification of strategies to target the multi-layered challenges of integrating evidence-based CIH interventions into practice.

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Published In

Pain Manag Nurs

DOI

EISSN

1532-8635

Publication Date

August 2026

Volume

27

Issue

4

Start / End Page

436 / 442

Location

United States

Related Subject Headings

  • Workflow
  • United States
  • Qualitative Research
  • Pragmatic Clinical Trials as Topic
  • Pain Management
  • Nursing
  • National Institutes of Health (U.S.)
  • Interviews as Topic
  • Integrative Medicine
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ibemere, S. O., Knisely, M. R., Akpotu, I., Darby, J. E., de Martelly, V. A., Doorenbos, A. Z., … Patil, C. L. (2026). Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory. Pain Manag Nurs, 27(4), 436–442. https://doi.org/10.1016/j.pmn.2025.12.015
Ibemere, Stephanie O., Mitchell R. Knisely, Ivy Akpotu, Juanita E. Darby, Victoria A. de Martelly, Ardith Z. Doorenbos, Miriam O. Ezenwa, et al. “Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory.Pain Manag Nurs 27, no. 4 (August 2026): 436–42. https://doi.org/10.1016/j.pmn.2025.12.015.
Ibemere, Stephanie O., et al. “Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory.Pain Manag Nurs, vol. 27, no. 4, Aug. 2026, pp. 436–42. Pubmed, doi:10.1016/j.pmn.2025.12.015.
Ibemere SO, Knisely MR, Akpotu I, Darby JE, de Martelly VA, Doorenbos AZ, Ezenwa MO, Matthie NS, Molokie RE, Schlaeger JM, Shah N, Wilkie DJ, Carroll CP, Patil CL. Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory. Pain Manag Nurs. 2026 Aug;27(4):436–442.
Journal cover image

Published In

Pain Manag Nurs

DOI

EISSN

1532-8635

Publication Date

August 2026

Volume

27

Issue

4

Start / End Page

436 / 442

Location

United States

Related Subject Headings

  • Workflow
  • United States
  • Qualitative Research
  • Pragmatic Clinical Trials as Topic
  • Pain Management
  • Nursing
  • National Institutes of Health (U.S.)
  • Interviews as Topic
  • Integrative Medicine
  • Humans