The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy.
Publication
, Journal Article
Bild, AH; Sangar, MC; McQuerry, JA; Ideker, T; Kopetz, S; Carey, L; Nath, A; Marcus, D; Regier, A; Rashid, N; Barzilay, R; Winer, E; Eddy, JA ...
Published in: Cancer Cell
March 9, 2026
ADAPT is a nationwide initiative to transform cancer care by detecting and responding to tumor evolution in real time. Integrating multimodal data, interpretable AI, and an evolutionary clinical trial platform, ADAPT predicts emerging resistance traits and guides treatment adjustments as tumors change. A unified national infrastructure enables continuous learning across patients, linking discovery directly to care. By making therapy responsive to tumor changes, ADAPT delivers a scalable model designed to improve outcomes in precision oncology.
Duke Scholars
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
March 9, 2026
Volume
44
Issue
3
Start / End Page
449 / 454
Location
United States
Related Subject Headings
- Precision Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Medical Oncology
- Humans
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Bild, A. H., Sangar, M. C., McQuerry, J. A., Ideker, T., Kopetz, S., Carey, L., … ADAPT Consortium. (2026). The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. Cancer Cell, 44(3), 449–454. https://doi.org/10.1016/j.ccell.2025.12.008
Bild, Andrea H., Michelle C. Sangar, Jasmine A. McQuerry, Trey Ideker, Scott Kopetz, Lisa Carey, Aritro Nath, et al. “The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy.” Cancer Cell 44, no. 3 (March 9, 2026): 449–54. https://doi.org/10.1016/j.ccell.2025.12.008.
Bild AH, Sangar MC, McQuerry JA, Ideker T, Kopetz S, Carey L, et al. The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. Cancer Cell. 2026 Mar 9;44(3):449–54.
Bild, Andrea H., et al. “The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy.” Cancer Cell, vol. 44, no. 3, Mar. 2026, pp. 449–54. Pubmed, doi:10.1016/j.ccell.2025.12.008.
Bild AH, Sangar MC, McQuerry JA, Ideker T, Kopetz S, Carey L, Nath A, Marcus D, Regier A, Rashid N, Barzilay R, Winer E, Salgia R, Malhotra J, Gentles A, Buetow K, Mahmood F, Markman DW, Eddy JA, ADAPT Consortium. The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. Cancer Cell. 2026 Mar 9;44(3):449–454.
Published In
Cancer Cell
DOI
EISSN
1878-3686
Publication Date
March 9, 2026
Volume
44
Issue
3
Start / End Page
449 / 454
Location
United States
Related Subject Headings
- Precision Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Medical Oncology
- Humans
- 3211 Oncology and carcinogenesis
- 3101 Biochemistry and cell biology