Squamous Precursor Lesions of the Vulva: A Practical Approach.
Publication
, Journal Article
Crimmins, J; Schneider, MM; Selim, MA
Published in: Dermatol Clin
April 2026
Vulvar squamous cell carcinoma and its precursors are heterogeneous and classified into 3 biologically distinct subgroups: human papillomavirus (HPV)-associated, HPV-independent TP53-mutated, and HPV-independent TP53-wild type. Although nomenclature is established for HPV-associated high-grade squamous intraepithelial lesion and TP53-mutated differentiated vulvar intraepithelial neoplasia lesions, terminology for precursors in the TP53-wild-type subgroup is evolving. Accurate classification is essential, as prognosis, progression risk, and recurrence rates differ among subgroups. Diagnosis relies on integrated assessment of clinical presentation, histopathology, and immunophenotype, particularly p16 and p53 expression.
Duke Scholars
Published In
Dermatol Clin
DOI
EISSN
1558-0520
Publication Date
April 2026
Volume
44
Issue
2
Start / End Page
191 / 203
Location
United States
Related Subject Headings
- Vulvar Neoplasms
- Tumor Suppressor Protein p53
- Squamous Intraepithelial Lesions
- Precancerous Conditions
- Papillomavirus Infections
- Mutation
- Humans
- Female
- Dermatology & Venereal Diseases
- Carcinoma, Squamous Cell
Citation
APA
Chicago
ICMJE
MLA
NLM
Crimmins, J., Schneider, M. M., & Selim, M. A. (2026). Squamous Precursor Lesions of the Vulva: A Practical Approach. Dermatol Clin, 44(2), 191–203. https://doi.org/10.1016/j.det.2026.01.015
Crimmins, Jennifer, Michelle M. Schneider, and M Angelica Selim. “Squamous Precursor Lesions of the Vulva: A Practical Approach.” Dermatol Clin 44, no. 2 (April 2026): 191–203. https://doi.org/10.1016/j.det.2026.01.015.
Crimmins J, Schneider MM, Selim MA. Squamous Precursor Lesions of the Vulva: A Practical Approach. Dermatol Clin. 2026 Apr;44(2):191–203.
Crimmins, Jennifer, et al. “Squamous Precursor Lesions of the Vulva: A Practical Approach.” Dermatol Clin, vol. 44, no. 2, Apr. 2026, pp. 191–203. Pubmed, doi:10.1016/j.det.2026.01.015.
Crimmins J, Schneider MM, Selim MA. Squamous Precursor Lesions of the Vulva: A Practical Approach. Dermatol Clin. 2026 Apr;44(2):191–203.
Published In
Dermatol Clin
DOI
EISSN
1558-0520
Publication Date
April 2026
Volume
44
Issue
2
Start / End Page
191 / 203
Location
United States
Related Subject Headings
- Vulvar Neoplasms
- Tumor Suppressor Protein p53
- Squamous Intraepithelial Lesions
- Precancerous Conditions
- Papillomavirus Infections
- Mutation
- Humans
- Female
- Dermatology & Venereal Diseases
- Carcinoma, Squamous Cell