DENV-4 infection suppresses transcription of DNA repair genes.
Journal articles
- Journal Article
Lamkin, EN; Reich, J; Victor, JA; Guyette, M; Kothandaraman, N; Gupta, V; Harding, AT; Jordan, TX; Gehrke, L; Zhou, P; tenOever, B; Chatterjee, N
Published in: Proc Natl Acad Sci U S A
August 11, 2026
The molecular mechanisms behind Dengue virus-dependent host pathogenesis, especially genome instability, remain largely unclear. This RNA virus causes a debilitating disease during active infection and presents future risks of postdengue syndromes, leukemia, and DNA damage in the blood cells of infected patients, with the underlying mechanisms unknown. In this study, we show that DENV-4 infection induces significant DNA damage and suppresses the transcription of genes involved in DNA repair and select mutagenic translesion synthesis (TLS) polymerases, indicating that DENV-4-dependent pathobiology leaves durable biological "scars" that incrementally increase chronic disease risk, including carcinogenesis and postdengue syndromes.
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Published In
Proc Natl Acad Sci U S A
DOI
EISSN
1091-6490
Publication Date
August 11, 2026
Volume
123
Issue
32
Start / End Page
e2536909123
Location
United States
Related Subject Headings
- Translesion DNA Synthesis
- Transcription, Genetic
- Humans
- Genomic Instability
- Dengue Virus
- Dengue
- DNA Repair
- DNA Damage
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Lamkin, E. N., Reich, J., Victor, J. A., Guyette, M., Kothandaraman, N., Gupta, V., … Chatterjee, N. (2026). DENV-4 infection suppresses transcription of DNA repair genes. Proc Natl Acad Sci U S A, 123(32), e2536909123. https://doi.org/10.1073/pnas.2536909123
Lamkin, Erica N., Jessica Reich, Josh A. Victor, Madison Guyette, Naveen Kothandaraman, Vihit Gupta, Alfred T. Harding, et al. “DENV-4 infection suppresses transcription of DNA repair genes.” Proc Natl Acad Sci U S A 123, no. 32 (August 11, 2026): e2536909123. https://doi.org/10.1073/pnas.2536909123.
Lamkin EN, Reich J, Victor JA, Guyette M, Kothandaraman N, Gupta V, et al. DENV-4 infection suppresses transcription of DNA repair genes. Proc Natl Acad Sci U S A. 2026 Aug 11;123(32):e2536909123.
Lamkin, Erica N., et al. “DENV-4 infection suppresses transcription of DNA repair genes.” Proc Natl Acad Sci U S A, vol. 123, no. 32, Aug. 2026, p. e2536909123. Pubmed, doi:10.1073/pnas.2536909123.
Lamkin EN, Reich J, Victor JA, Guyette M, Kothandaraman N, Gupta V, Harding AT, Jordan TX, Gehrke L, Zhou P, tenOever B, Chatterjee N. DENV-4 infection suppresses transcription of DNA repair genes. Proc Natl Acad Sci U S A. 2026 Aug 11;123(32):e2536909123.
Published In
Proc Natl Acad Sci U S A
DOI
EISSN
1091-6490
Publication Date
August 11, 2026
Volume
123
Issue
32
Start / End Page
e2536909123
Location
United States
Related Subject Headings
- Translesion DNA Synthesis
- Transcription, Genetic
- Humans
- Genomic Instability
- Dengue Virus
- Dengue
- DNA Repair
- DNA Damage