Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.
Publication
, Journal Article
Frush, DP; McNamara, JO
Published in: Exp Neurol
April 1986
We studied the occurrence of wet dog shakes during the evolution of kindling induced by electrical stimulation of the lateral entorhinal cortex. Wet dog shakes occur with high incidence, particularly early in development of kindling. We also demonstrated that microinjection of colchicine into the hippocampus, but not into neocortex, produced a 95% suppression of wet dog shakes. We propose that the suppressive effect of colchicine is mediated by destruction of dentate granule cells. Together with evidence from other investigations, these data support the idea that activation of hippocampal neurons is essential for production of wet dog shakes induced by stimulation of the limbic system.
Duke Scholars
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
April 1986
Volume
92
Issue
1
Start / End Page
102 / 113
Location
United States
Related Subject Headings
- Rats
- Neurology & Neurosurgery
- Male
- Limbic System
- Kindling, Neurologic
- Hippocampus
- Colchicine
- Cerebellar Nuclei
- Behavior, Animal
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Frush, D. P., & McNamara, J. O. (1986). Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. Exp Neurol, 92(1), 102–113. https://doi.org/10.1016/0014-4886(86)90128-7
Frush, D. P., and J. O. McNamara. “Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.” Exp Neurol 92, no. 1 (April 1986): 102–13. https://doi.org/10.1016/0014-4886(86)90128-7.
Frush DP, McNamara JO. Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. Exp Neurol. 1986 Apr;92(1):102–13.
Frush, D. P., and J. O. McNamara. “Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.” Exp Neurol, vol. 92, no. 1, Apr. 1986, pp. 102–13. Pubmed, doi:10.1016/0014-4886(86)90128-7.
Frush DP, McNamara JO. Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. Exp Neurol. 1986 Apr;92(1):102–113.
Published In
Exp Neurol
DOI
ISSN
0014-4886
Publication Date
April 1986
Volume
92
Issue
1
Start / End Page
102 / 113
Location
United States
Related Subject Headings
- Rats
- Neurology & Neurosurgery
- Male
- Limbic System
- Kindling, Neurologic
- Hippocampus
- Colchicine
- Cerebellar Nuclei
- Behavior, Animal
- Animals