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Journal cover image

Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick.

Publication ,  Journal Article
Wall, NA; Hogan, BL
Published in: Mech Dev
November 1995

Expression of Fgf-8, Bmp-4, Bmp-7, and shh in the branchial arches of the chick embryo is examined by in situ hybridization. Fgf-8 expression is initially broad and diffuse, becoming more tightly restricted, particularly in the epithelium of the posterior ectodermal margin (PEM) of the 2nd branchial arch. Bmp-7 transcripts, first seen at stage 12 in discrete regions corresponding to the developing branchial clefts, are later detected in both clefts and arches, including the PEM of the 2nd arch while Bmp-4 transcripts are detected at stage 18 in the distal tips of the arches. Shh expression remains localized, overlapping with both Bmp-7 and Fgf-8 in the PEM of the 2nd arch at stages 16 and 18. Based on these data, a model is proposed for the role of these signalling molecules in branchial arch development.

Duke Scholars

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

November 1995

Volume

53

Issue

3

Start / End Page

383 / 392

Location

Ireland

Related Subject Headings

  • Trans-Activators
  • Skull
  • Proteins
  • In Situ Hybridization
  • Hedgehog Proteins
  • Growth Substances
  • Fibroblast Growth Factors
  • Facial Bones
  • Embryonic Induction
  • Ectoderm
 

Citation

Journal cover image

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

November 1995

Volume

53

Issue

3

Start / End Page

383 / 392

Location

Ireland

Related Subject Headings

  • Trans-Activators
  • Skull
  • Proteins
  • In Situ Hybridization
  • Hedgehog Proteins
  • Growth Substances
  • Fibroblast Growth Factors
  • Facial Bones
  • Embryonic Induction
  • Ectoderm