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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.

Publication ,  Journal Article
Ichiki, T; Labosky, PA; Shiota, C; Okuyama, S; Imagawa, Y; Fogo, A; Niimura, F; Ichikawa, I; Hogan, BL; Inagami, T
Published in: Nature
October 26, 1995

There are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-known pressor and mitogenic effects of angiotensin II, but the signalling mechanism and physiological role of AT2 has not been established. Its abundant expression in fetal tissues and certain brain nuclei suggest possible roles in growth, development and neuronal functions. Here we report the unexpected finding that the targeted disruption of the mouse AT2 gene resulted in a significant increase in blood pressure and increased sensitivity to the pressor action of angiotensin II. Thus AT2 mediates a depressor effect and antagonizes the AT1-mediated pressor action of angiotensin II. In addition, disruption of the AT2 gene attenuated exploratory behaviour and lowered body temperature. Our results show that angiotensin II activates AT1 and AT2, which have mutually counteracting haemodynamic effects, and that AT2 regulates central nervous system functions, including behaviour.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 26, 1995

Volume

377

Issue

6551

Start / End Page

748 / 750

Location

England

Related Subject Headings

  • Vasoconstrictor Agents
  • Receptors, Angiotensin
  • Mice, Inbred ICR
  • Mice, Inbred C57BL
  • Mice
  • Male
  • General Science & Technology
  • Gene Targeting
  • Female
  • Exploratory Behavior
 

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Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., … Inagami, T. (1995). Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature, 377(6551), 748–750. https://doi.org/10.1038/377748a0
Ichiki, T., P. A. Labosky, C. Shiota, S. Okuyama, Y. Imagawa, A. Fogo, F. Niimura, I. Ichikawa, B. L. Hogan, and T. Inagami. “Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.Nature 377, no. 6551 (October 26, 1995): 748–50. https://doi.org/10.1038/377748a0.
Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995 Oct 26;377(6551):748–50.
Ichiki, T., et al. “Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.Nature, vol. 377, no. 6551, Oct. 1995, pp. 748–50. Pubmed, doi:10.1038/377748a0.
Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, Inagami T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995 Oct 26;377(6551):748–750.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

October 26, 1995

Volume

377

Issue

6551

Start / End Page

748 / 750

Location

England

Related Subject Headings

  • Vasoconstrictor Agents
  • Receptors, Angiotensin
  • Mice, Inbred ICR
  • Mice, Inbred C57BL
  • Mice
  • Male
  • General Science & Technology
  • Gene Targeting
  • Female
  • Exploratory Behavior