Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).

Publication ,  Journal Article
Wall, NA; Blessing, M; Wright, CV; Hogan, BL
Published in: J Cell Biol
January 1993

DVR-6 (BMP-6 or Vgr-1) is a member of the TGF-beta superfamily of polypeptide signaling molecules. In situ hybridization studies have previously shown that DVR-6 RNA is expressed in a variety of cell types in the mouse embryo, but no information has been available on protein localization and biosynthesis. We have produced a polyclonal antibody to the proregion of DVR-6 and used it to localize the protein in whole mount and sectioned embryonic, newborn, and adult mouse tissues. DVR-6 protein is expressed in the mouse nervous system beginning at 9.5 days postcoitum (d.p.c.) and continues through adulthood. A variety of epithelial tissues also produce DVR-6 protein, including the suprabasal layer of the skin, bronchiolar epithelium, and the cornea. Additionally, a stably transfected cell line, BMGE+H/D6c4, is used to study the biosynthesis of DVR-6 protein and evidence is presented for translational regulation of DVR-6 expression.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Cell Biol

DOI

ISSN

0021-9525

Publication Date

January 1993

Volume

120

Issue

2

Start / End Page

493 / 502

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Recombinant Fusion Proteins
  • Proteins
  • Protein Biosynthesis
  • Nervous System
  • Mice
  • Mammary Glands, Animal
  • Immunohistochemistry
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wall, N. A., Blessing, M., Wright, C. V., & Hogan, B. L. (1993). Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol, 120(2), 493–502. https://doi.org/10.1083/jcb.120.2.493
Wall, N. A., M. Blessing, C. V. Wright, and B. L. Hogan. “Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).J Cell Biol 120, no. 2 (January 1993): 493–502. https://doi.org/10.1083/jcb.120.2.493.
Wall NA, Blessing M, Wright CV, Hogan BL. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol. 1993 Jan;120(2):493–502.
Wall, N. A., et al. “Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).J Cell Biol, vol. 120, no. 2, Jan. 1993, pp. 493–502. Pubmed, doi:10.1083/jcb.120.2.493.
Wall NA, Blessing M, Wright CV, Hogan BL. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol. 1993 Jan;120(2):493–502.

Published In

J Cell Biol

DOI

ISSN

0021-9525

Publication Date

January 1993

Volume

120

Issue

2

Start / End Page

493 / 502

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Recombinant Fusion Proteins
  • Proteins
  • Protein Biosynthesis
  • Nervous System
  • Mice
  • Mammary Glands, Animal
  • Immunohistochemistry
  • Humans