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Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.

Publication ,  Journal Article
Zhao, GQ; Liaw, L; Hogan, BL
Published in: Development
March 1998

The murine Bmp8a and Bmp8b genes are tightly linked on mouse chromosome 4 and have similar expression during reproduction. Previous studies have shown that targeted mutagenesis of Bmp8b causes male infertility due to germ cell degeneration. To investigate the function of Bmp8a, we have inactivated the gene by homologous recombination. Heterozygous and homozygous Bmp8a mutants reveal normal embryonic and postnatal development. Despite high levels of Bmp8a expression in the deciduum, homozygous mutant females have normal fertility, suggesting that the gene is not essential for female reproduction. Bmp8a and Bmp8b are expressed in similar patterns in male germ cells. Unlike homozygous Bmp8btm1 mutants, homozygous Bmp8atm1 males do not show obvious germ cell defects during the initiation of spermatogenesis. However, germ cell degeneration is observed in 47% of adult homozygous Bmp8atm1 males, establishing a role of Bmp8a in the maintenance of spermatogenesis. A small proportion of the mating homozygous Bmp8atm1 males also show degeneration of the epididymal epithelium, indicating a novel role for BMPs in the control of epididymal function.

Duke Scholars

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

March 1998

Volume

125

Issue

6

Start / End Page

1103 / 1112

Location

England

Related Subject Headings

  • Testis
  • Spermatogenesis
  • Sequence Homology, Nucleic Acid
  • Pregnancy
  • Polymerase Chain Reaction
  • Mutagenesis
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice
  • Male
 

Citation

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Zhao, G. Q., Liaw, L., & Hogan, B. L. (1998). Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Development, 125(6), 1103–1112. https://doi.org/10.1242/dev.125.6.1103
Zhao, G. Q., L. Liaw, and B. L. Hogan. “Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.Development 125, no. 6 (March 1998): 1103–12. https://doi.org/10.1242/dev.125.6.1103.
Zhao, G. Q., et al. “Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.Development, vol. 125, no. 6, Mar. 1998, pp. 1103–12. Pubmed, doi:10.1242/dev.125.6.1103.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

March 1998

Volume

125

Issue

6

Start / End Page

1103 / 1112

Location

England

Related Subject Headings

  • Testis
  • Spermatogenesis
  • Sequence Homology, Nucleic Acid
  • Pregnancy
  • Polymerase Chain Reaction
  • Mutagenesis
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice
  • Male