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Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions.

Publication ,  Journal Article
Simon, SA; McIntosh, TJ
Published in: Biochim Biophys Acta
June 13, 1984

It has been shown recently by Rowe ((1983) Biochemistry 22, 3299-3305) that ethanol has a 'biphasic' effect on the transition temperature (Tm) of phosphatidylcholine bilayers, reducing Tm at low concentrations but increasing Tm at high concentrations. Our X-ray diffraction data show that this reversal of Tm is a consequence of the induction of an unusual gel phase, where the lipid hydrocarbon chains from apposing monolayers fully interpenetrate or interdigitate. The properties of this interdigitated phase also explain the lipid chain length dependence of the reversal in the Tm versus ethanol concentration curves and the narrow width of the transition at high ethanol concentrations, as well as spectroscopic and calorimetric data from lipid suspensions containing other drugs such as methanol, benzyl alcohol, phenyl ethanol, and chlorpromazine.

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Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

June 13, 1984

Volume

773

Issue

1

Start / End Page

169 / 172

Location

Netherlands

Related Subject Headings

  • X-Ray Diffraction
  • Thermodynamics
  • Phosphatidylcholines
  • Molecular Conformation
  • Lipid Bilayers
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences
 

Citation

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Simon, S. A., & McIntosh, T. J. (1984). Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions. Biochim Biophys Acta, 773(1), 169–172. https://doi.org/10.1016/0005-2736(84)90562-5
Simon, S. A., and T. J. McIntosh. “Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions.Biochim Biophys Acta 773, no. 1 (June 13, 1984): 169–72. https://doi.org/10.1016/0005-2736(84)90562-5.
Simon SA, McIntosh TJ. Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions. Biochim Biophys Acta. 1984 Jun 13;773(1):169–72.
Simon, S. A., and T. J. McIntosh. “Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions.Biochim Biophys Acta, vol. 773, no. 1, June 1984, pp. 169–72. Pubmed, doi:10.1016/0005-2736(84)90562-5.
Simon SA, McIntosh TJ. Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions. Biochim Biophys Acta. 1984 Jun 13;773(1):169–172.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

June 13, 1984

Volume

773

Issue

1

Start / End Page

169 / 172

Location

Netherlands

Related Subject Headings

  • X-Ray Diffraction
  • Thermodynamics
  • Phosphatidylcholines
  • Molecular Conformation
  • Lipid Bilayers
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences