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The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.

Publication ,  Journal Article
Drenth, J; Low, BW; Richardson, JS; Wright, CS
Published in: J Biol Chem
April 10, 1980

The three-dimensional structures of the snake venom postsynaptic neurotoxins and of the domains in wheat germ agglutinin show a remarkably similar overall folding pattern, consisting of equivalently placed, but variably sized loops which are held together by four similarly positioned disulfide bonds. Furthermore, occurrence of this wheat germ agglutinin-neurotoxin domain fold is predicted not only in the snake venom cardiotoxins and cytotoxins with neurotoxin-matched half-cystine sequence positions, but also for two small plant proteins, hevein and ragweed pollen allergen Ra5, on the basis of a nearly exact match of their half-cystine, sequence positions with those of the wheat germ agglutinin domain.

Duke Scholars

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

April 10, 1980

Volume

255

Issue

7

Start / End Page

2652 / 2655

Location

United States

Related Subject Headings

  • Wheat Germ Agglutinins
  • Protein Conformation
  • Protein Binding
  • Pollen
  • Plant Lectins
  • Neurotoxins
  • Lectins
  • Erabutoxins
  • Elapid Venoms
  • Disulfides
 

Citation

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MLA
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Drenth, J., Low, B. W., Richardson, J. S., & Wright, C. S. (1980). The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. J Biol Chem, 255(7), 2652–2655.
Drenth, J., B. W. Low, J. S. Richardson, and C. S. Wright. “The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.J Biol Chem 255, no. 7 (April 10, 1980): 2652–55.
Drenth J, Low BW, Richardson JS, Wright CS. The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. J Biol Chem. 1980 Apr 10;255(7):2652–5.
Drenth, J., et al. “The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core.J Biol Chem, vol. 255, no. 7, Apr. 1980, pp. 2652–55.
Drenth J, Low BW, Richardson JS, Wright CS. The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. J Biol Chem. 1980 Apr 10;255(7):2652–2655.

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

April 10, 1980

Volume

255

Issue

7

Start / End Page

2652 / 2655

Location

United States

Related Subject Headings

  • Wheat Germ Agglutinins
  • Protein Conformation
  • Protein Binding
  • Pollen
  • Plant Lectins
  • Neurotoxins
  • Lectins
  • Erabutoxins
  • Elapid Venoms
  • Disulfides