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Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.

Publication ,  Journal Article
Nataraj, C; Oliverio, MI; Mannon, RB; Mannon, PJ; Audoly, LP; Amuchastegui, CS; Ruiz, P; Smithies, O; Coffman, TM
Published in: J Clin Invest
December 1999

The renin-angiotensin system (RAS) is a key regulator of vascular tone and blood pressure. In addition, angiotensin II also has a number of cellular effects that may contribute to disease pathogenesis. Using Agtr1a(-/-) mice, which lack AT(1A) receptors for angiotensin II, we have identified a novel function of the RAS to modulate the immune system. We find that angiotensin II, acting through type 1 (AT(1)) receptors on immune cells, triggers the proliferation of splenic lymphocytes. These actions contribute to the vigor of cellular alloimmune responses. Within lymphoid organs, sufficient components of the RAS are present to activate AT(1) receptors during an immune response, promoting cell growth. These actions require activation of calcineurin phosphatase. In an in vivo model of cardiac transplantation, the absence of AT(1) signaling accentuates the immunosuppressive effects of the calcineurin inhibitor cyclosporine. We conclude that inhibition of AT(1) receptor signaling should be useful as an anti-inflammatory and immunosuppressive therapy. Furthermore, the actions of the RAS to promote lymphocyte activation may contribute to inflammation that characterizes a number of diseases of the heart and the vascular system.

Duke Scholars

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

December 1999

Volume

104

Issue

12

Start / End Page

1693 / 1701

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Peptidyl-Dipeptidase A
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Calcineurin
 

Citation

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Nataraj, C., Oliverio, M. I., Mannon, R. B., Mannon, P. J., Audoly, L. P., Amuchastegui, C. S., … Coffman, T. M. (1999). Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest, 104(12), 1693–1701. https://doi.org/10.1172/JCI7451
Nataraj, C., M. I. Oliverio, R. B. Mannon, P. J. Mannon, L. P. Audoly, C. S. Amuchastegui, P. Ruiz, O. Smithies, and T. M. Coffman. “Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.J Clin Invest 104, no. 12 (December 1999): 1693–1701. https://doi.org/10.1172/JCI7451.
Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, et al. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest. 1999 Dec;104(12):1693–701.
Nataraj, C., et al. “Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.J Clin Invest, vol. 104, no. 12, Dec. 1999, pp. 1693–701. Pubmed, doi:10.1172/JCI7451.
Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, Ruiz P, Smithies O, Coffman TM. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest. 1999 Dec;104(12):1693–1701.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

December 1999

Volume

104

Issue

12

Start / End Page

1693 / 1701

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Peptidyl-Dipeptidase A
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Calcineurin