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Immunoglobulin G subclass deficiency: fact or fancy?

Publication ,  Journal Article
Buckley, RH
Published in: Curr Allergy Asthma Rep
September 2002

Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an inability to produce antibodies to polysaccharide antigens, it is difficult to know the true biologic significance of the many reported IgG subclass deficiencies. Completely asymptomatic individuals who totally lack IgG1, IgG2, IgG4, or IgA1 because of heavy-chain gene deletions have been described as producing antibodies normally. In addition, numerous healthy children who have low levels of IgG2 but normal responses to polysaccharide antigens when immunized have been similarly described. From these observations, it can be concluded that IgG subclass measurement is not very helpful in the general assessment of immune function. Such assays provide no information about the patient's capacity to produce specific antibodies to protein, polysaccharide, or viral antigens.

Duke Scholars

Published In

Curr Allergy Asthma Rep

DOI

ISSN

1529-7322

Publication Date

September 2002

Volume

2

Issue

5

Start / End Page

356 / 360

Location

United States

Related Subject Headings

  • Protein Isoforms
  • Immunoglobulins
  • Immunoglobulin G
  • Humans
  • Allergy
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Buckley, R. H. (2002). Immunoglobulin G subclass deficiency: fact or fancy? Curr Allergy Asthma Rep, 2(5), 356–360. https://doi.org/10.1007/s11882-002-0067-1
Buckley, Rebecca H. “Immunoglobulin G subclass deficiency: fact or fancy?Curr Allergy Asthma Rep 2, no. 5 (September 2002): 356–60. https://doi.org/10.1007/s11882-002-0067-1.
Buckley RH. Immunoglobulin G subclass deficiency: fact or fancy? Curr Allergy Asthma Rep. 2002 Sep;2(5):356–60.
Buckley, Rebecca H. “Immunoglobulin G subclass deficiency: fact or fancy?Curr Allergy Asthma Rep, vol. 2, no. 5, Sept. 2002, pp. 356–60. Pubmed, doi:10.1007/s11882-002-0067-1.
Buckley RH. Immunoglobulin G subclass deficiency: fact or fancy? Curr Allergy Asthma Rep. 2002 Sep;2(5):356–360.
Journal cover image

Published In

Curr Allergy Asthma Rep

DOI

ISSN

1529-7322

Publication Date

September 2002

Volume

2

Issue

5

Start / End Page

356 / 360

Location

United States

Related Subject Headings

  • Protein Isoforms
  • Immunoglobulins
  • Immunoglobulin G
  • Humans
  • Allergy
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology