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IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome.

Publication ,  Journal Article
Spiegelberg, HL; Thompson, LF; McNeil, D; Buckley, RH
Published in: Int Arch Allergy Appl Immunol
1985

Patients with the hyper-IgE syndrome have greatly elevated percentages of IgE Fc receptor (Fc epsilon R)-positive B cells, but they have less than 0.1% Fc epsilon R+ T cells (T epsilon cells) and few, if any, Fc epsilon R+ natural killer cells. They also have markedly decreased numbers of IgG receptor positive (Fc gamma R+) T cells (T gamma cells). Patients with the hyper-IgE syndrome resemble in this respect patients with severe atopic dermatitis. Since a portion of T epsilon and T gamma cells of mildly atopic patients react with monoclonal antibody OKT8, they may have a suppressor function. However, whether the low number of T epsilon cells is responsible for the high IgE serum level in hyper-IgE syndrome and atopic dermatitis patients remains to be demonstrated. Attempts to obtain a reliable assay for human IgE synthesis in vitro to investigate the function of Fc epsilon R-positive lymphocytes proved to be difficult. Even isolated B cells from atopic donors seldom produced more than twice the quantity of IgE released from cells incubated in the presence of the protein synthesis inhibitor cycloheximide.

Duke Scholars

Published In

Int Arch Allergy Appl Immunol

DOI

ISSN

0020-5915

Publication Date

1985

Volume

77

Issue

1-2

Start / End Page

277 / 279

Location

Switzerland

Related Subject Headings

  • T-Lymphocytes
  • Syndrome
  • Receptors, IgE
  • Receptors, Fc
  • Lymphocytes
  • Killer Cells, Natural
  • Immunoglobulin E
  • Hypergammaglobulinemia
  • Humans
  • Dermatitis, Contact
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Spiegelberg, H. L., Thompson, L. F., McNeil, D., & Buckley, R. H. (1985). IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. Int Arch Allergy Appl Immunol, 77(1–2), 277–279. https://doi.org/10.1159/000233809
Spiegelberg, H. L., L. F. Thompson, D. McNeil, and R. H. Buckley. “IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome.Int Arch Allergy Appl Immunol 77, no. 1–2 (1985): 277–79. https://doi.org/10.1159/000233809.
Spiegelberg HL, Thompson LF, McNeil D, Buckley RH. IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. Int Arch Allergy Appl Immunol. 1985;77(1–2):277–9.
Spiegelberg, H. L., et al. “IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome.Int Arch Allergy Appl Immunol, vol. 77, no. 1–2, 1985, pp. 277–79. Pubmed, doi:10.1159/000233809.
Spiegelberg HL, Thompson LF, McNeil D, Buckley RH. IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. Int Arch Allergy Appl Immunol. 1985;77(1–2):277–279.

Published In

Int Arch Allergy Appl Immunol

DOI

ISSN

0020-5915

Publication Date

1985

Volume

77

Issue

1-2

Start / End Page

277 / 279

Location

Switzerland

Related Subject Headings

  • T-Lymphocytes
  • Syndrome
  • Receptors, IgE
  • Receptors, Fc
  • Lymphocytes
  • Killer Cells, Natural
  • Immunoglobulin E
  • Hypergammaglobulinemia
  • Humans
  • Dermatitis, Contact