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Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies.

Publication ,  Journal Article
Björkander, J; Hammarström, L; Smith, CI; Buckley, RH; Cunningham-Rundles, C; Hanson, LA
Published in: J Clin Immunol
January 1987

Sera from three hundred five patients with immunoglobulin deficiencies were analyzed for the presence of anti-IgA antibodies by using indirect agglutination and enzyme-linked immunosorbent assay (ELISA). Anti-IgA antibodies were observed in 15 of 68 (22%) patients with hypogammaglobulinemia and 53 of 185 (29%) patients with selective IgA deficiency, both groups having serum IgA less than 0.05 g/liter. The highest frequency, 6 of 10 or 60%, was noted for patients with a combined IgA-IgG2 deficiency. No anti-IgA antibodies were detected in 25 patients with serum IgA between 0.05 and 0.27 g/liter and normal amounts of serum IgM and IgG or in 17 patients with hypogammaglobulinemia who had serum IgA of 0.05-0.7 g/liter. The anti-IgA antibodies were primarily of the IgG class, but IgD and IgM anti-IgA were occasionally found. IgE anti-IgA antibodies could not be detected with the presently used technique. The IgG anti-IgA antibodies were mainly of the IgG1 subclass but occasionally also of the subclasses IgG2, IgG3, and IgG4. Of eight patients with anti-IgA antibodies, seven tolerated Ig prophylaxis with a commercial immunoglobulin preparation low in IgA when given either intramuscularly or intravenously. The titers of anti-IgA in the sera of these patients did not rise in relation to the prophylaxis. Only one of the eight patients had a history of previous anaphylactic reactions to IgA-containing blood products. He tolerated six Ig infusions during 5 months with the IgA-depleted preparation without any adverse effects but showed increasing levels of anti-IgA antibodies and ultimately experienced a near-fatal reaction at the seventh infusion.

Duke Scholars

Published In

J Clin Immunol

DOI

ISSN

0271-9142

Publication Date

January 1987

Volume

7

Issue

1

Start / End Page

8 / 15

Location

Netherlands

Related Subject Headings

  • Immunotherapy
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulins
  • Immunoglobulin Isotypes
  • Immunoglobulin A
  • Immunization, Passive
  • IgA Deficiency
  • Humans
  • Antibodies, Anti-Idiotypic
 

Citation

APA
Chicago
ICMJE
MLA
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Björkander, J., Hammarström, L., Smith, C. I., Buckley, R. H., Cunningham-Rundles, C., & Hanson, L. A. (1987). Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. J Clin Immunol, 7(1), 8–15. https://doi.org/10.1007/BF00915419
Björkander, J., L. Hammarström, C. I. Smith, R. H. Buckley, C. Cunningham-Rundles, and L. A. Hanson. “Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies.J Clin Immunol 7, no. 1 (January 1987): 8–15. https://doi.org/10.1007/BF00915419.
Björkander J, Hammarström L, Smith CI, Buckley RH, Cunningham-Rundles C, Hanson LA. Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. J Clin Immunol. 1987 Jan;7(1):8–15.
Björkander, J., et al. “Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies.J Clin Immunol, vol. 7, no. 1, Jan. 1987, pp. 8–15. Pubmed, doi:10.1007/BF00915419.
Björkander J, Hammarström L, Smith CI, Buckley RH, Cunningham-Rundles C, Hanson LA. Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. J Clin Immunol. 1987 Jan;7(1):8–15.
Journal cover image

Published In

J Clin Immunol

DOI

ISSN

0271-9142

Publication Date

January 1987

Volume

7

Issue

1

Start / End Page

8 / 15

Location

Netherlands

Related Subject Headings

  • Immunotherapy
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulins
  • Immunoglobulin Isotypes
  • Immunoglobulin A
  • Immunization, Passive
  • IgA Deficiency
  • Humans
  • Antibodies, Anti-Idiotypic