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Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.

Publication ,  Journal Article
Cohen, MS; Isturiz, RE; Malech, HL; Root, RK; Wilfert, CM; Gutman, L; Buckley, RH
Published in: Am J Med
July 1981

Among 245 cases of chronic granulomatous disease which were evaluated, fungal infection occurred in 20.4 percent. Fungi encountered include Aspergillus, Torulopsis and Candida. In 18 percent of the patients with fungal infection, the disease was limited to soft tissue or bone; all did well. Most of the patients had fungal pneumonia and/or widely disseminated disease; diagnosis was usually confirmed by open lung biopsy. Patients with pneumonia or disseminated disease who received no therapy succumbed to infection, whereas more than half the patients who received antifungal therapy were cured. Modalities of treatment included antifungal chemotherapy, surgical removal of infected tissue and granulocyte transfusion. Although several patients showed dramatic improvement during granulocyte transfusions given in combination with antifungal chemotherapy, the improvement achieved was not statistically significant when compared with that achieved with chemotherapy alone. These results emphasized the importance of phagocytic cells in defense against fungi and the need for further evaluation of granulocyte transfusion therapy in compromised hosts in whom fungal infections develop.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

July 1981

Volume

71

Issue

1

Start / End Page

59 / 66

Location

United States

Related Subject Headings

  • Phagocytes
  • Mycoses
  • Male
  • Lung Diseases, Fungal
  • Infant
  • Humans
  • Granulomatous Disease, Chronic
  • Granulocytes
  • General & Internal Medicine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cohen, M. S., Isturiz, R. E., Malech, H. L., Root, R. K., Wilfert, C. M., Gutman, L., & Buckley, R. H. (1981). Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med, 71(1), 59–66. https://doi.org/10.1016/0002-9343(81)90259-x
Cohen, M. S., R. E. Isturiz, H. L. Malech, R. K. Root, C. M. Wilfert, L. Gutman, and R. H. Buckley. “Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.Am J Med 71, no. 1 (July 1981): 59–66. https://doi.org/10.1016/0002-9343(81)90259-x.
Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, et al. Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med. 1981 Jul;71(1):59–66.
Cohen, M. S., et al. “Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi.Am J Med, vol. 71, no. 1, July 1981, pp. 59–66. Pubmed, doi:10.1016/0002-9343(81)90259-x.
Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, Buckley RH. Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med. 1981 Jul;71(1):59–66.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

July 1981

Volume

71

Issue

1

Start / End Page

59 / 66

Location

United States

Related Subject Headings

  • Phagocytes
  • Mycoses
  • Male
  • Lung Diseases, Fungal
  • Infant
  • Humans
  • Granulomatous Disease, Chronic
  • Granulocytes
  • General & Internal Medicine
  • Female