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27. Transplantation immunology: organ and bone marrow.

Publication ,  Journal Article
Buckley, RH
Published in: J Allergy Clin Immunol
February 2003

The discovery of the human MHC in 1967 launched the field of organ and tissue transplantation. More than 800,000 such transplants have been performed during this time. Although matching of donor and recipient for MHC antigens was shown to be of great importance and continues to be so, the development of pharmacologic agents and antilymphocyte antibodies that interfere with the process of graft rejection has had a crucial role in the success of organ transplantation during the past 2 decades. Enormous progress has been made in understanding the immunologic mechanisms of graft rejection and of graft-versus-host disease. The roles of antibodies, antigen-presenting cells, helper and cytotoxic T cells, immune cell surface molecules, and signaling mechanisms and the cytokines they release have been clarified. This understanding is leading to the development of newer immunosuppressive agents targeting various components of the rejection process. Combinations of these agents work synergistically, leading to lower doses and reduced toxicity. Similarly, the development of effective T-cell depletion techniques has been of great importance for bone marrow transplantation when an HLA-identical sibling is not available. The major obstacle to the performance of solid organ transplantation currently is the shortage of donor organs.

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Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

February 2003

Volume

111

Issue

2 Suppl

Start / End Page

S733 / S744

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Organ Transplantation
  • Immunosuppression Therapy
  • Humans
  • Histocompatibility Testing
  • Graft Rejection
  • Bone Marrow Transplantation
  • Antigens
  • Allergy
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckley, R. H. (2003). 27. Transplantation immunology: organ and bone marrow. J Allergy Clin Immunol, 111(2 Suppl), S733–S744. https://doi.org/10.1067/mai.2003.142
Buckley, Rebecca H. “27. Transplantation immunology: organ and bone marrow.J Allergy Clin Immunol 111, no. 2 Suppl (February 2003): S733–44. https://doi.org/10.1067/mai.2003.142.
Buckley RH. 27. Transplantation immunology: organ and bone marrow. J Allergy Clin Immunol. 2003 Feb;111(2 Suppl):S733–44.
Buckley, Rebecca H. “27. Transplantation immunology: organ and bone marrow.J Allergy Clin Immunol, vol. 111, no. 2 Suppl, Feb. 2003, pp. S733–44. Pubmed, doi:10.1067/mai.2003.142.
Buckley RH. 27. Transplantation immunology: organ and bone marrow. J Allergy Clin Immunol. 2003 Feb;111(2 Suppl):S733–S744.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

February 2003

Volume

111

Issue

2 Suppl

Start / End Page

S733 / S744

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Organ Transplantation
  • Immunosuppression Therapy
  • Humans
  • Histocompatibility Testing
  • Graft Rejection
  • Bone Marrow Transplantation
  • Antigens
  • Allergy
  • 3204 Immunology