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Advantage of the Mark-III FEL for biophysical research and biomedical applications.

Publication ,  Journal Article
Edwards, GS; Hutson, MS
Published in: Journal of synchrotron radiation
September 2003

Although 6.45 micro m is not the strongest absorption band of biological tissues in the mid-infrared, a Mark-III free-electron laser (FEL) tuned to this wavelength can efficiently ablate tissue while minimizing collateral damage. A model has previously been presented that explains this wavelength dependence as a competition between two dynamic processes--explosive vaporization of saline and denaturation of structural proteins. Here it is shown that this model predicts a 'sweet-spot' for each wavelength, i.e. a region of parameter space (incident intensity and pulse width) in which explosive vaporization is preceded by substantial protein denaturation. This sweet-spot is much larger for wavelengths where protein is the dominant chromophore. At other wavelengths, collateral damage may be minimized within the sweet-spot, but the maximum intensities and pulse widths in these regions are insufficient to remove tissue at surgically relevant rates.

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Published In

Journal of synchrotron radiation

DOI

EISSN

1600-5775

ISSN

0909-0495

Publication Date

September 2003

Volume

10

Issue

Pt 5

Start / End Page

354 / 357

Related Subject Headings

  • Swine
  • Sodium Chloride
  • Proteins
  • Models, Biological
  • Laser Therapy
  • Equipment Design
  • Corneal Stroma
  • Computer Simulation
  • Biophysics
  • Animals
 

Citation

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Edwards, G. S., & Hutson, M. S. (2003). Advantage of the Mark-III FEL for biophysical research and biomedical applications. Journal of Synchrotron Radiation, 10(Pt 5), 354–357. https://doi.org/10.1107/s0909049503007970
Edwards, Glenn S., and M Shane Hutson. “Advantage of the Mark-III FEL for biophysical research and biomedical applications.Journal of Synchrotron Radiation 10, no. Pt 5 (September 2003): 354–57. https://doi.org/10.1107/s0909049503007970.
Edwards GS, Hutson MS. Advantage of the Mark-III FEL for biophysical research and biomedical applications. Journal of synchrotron radiation. 2003 Sep;10(Pt 5):354–7.
Edwards, Glenn S., and M. Shane Hutson. “Advantage of the Mark-III FEL for biophysical research and biomedical applications.Journal of Synchrotron Radiation, vol. 10, no. Pt 5, Sept. 2003, pp. 354–57. Epmc, doi:10.1107/s0909049503007970.
Edwards GS, Hutson MS. Advantage of the Mark-III FEL for biophysical research and biomedical applications. Journal of synchrotron radiation. 2003 Sep;10(Pt 5):354–357.
Journal cover image

Published In

Journal of synchrotron radiation

DOI

EISSN

1600-5775

ISSN

0909-0495

Publication Date

September 2003

Volume

10

Issue

Pt 5

Start / End Page

354 / 357

Related Subject Headings

  • Swine
  • Sodium Chloride
  • Proteins
  • Models, Biological
  • Laser Therapy
  • Equipment Design
  • Corneal Stroma
  • Computer Simulation
  • Biophysics
  • Animals