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Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.

Publication ,  Journal Article
Johnson, JH; Ogawa, A; Chen, L; Orci, L; Newgard, CB; Alam, T; Unger, RH
Published in: Science
October 26, 1990

The role of defective glucose transport in the pathogenesis of noninsulin-dependent diabetes (NIDDM) was examined in Zucker diabetic fatty rats, a model of NIDDM. As in human NIDDM, insulin secretion was unresponsive to 20 mM glucose. Uptake of 3-O-methylglucose by islet cells was less than 19% of controls. The beta cell glucose transporter (GLUT-2) immunoreactivity and amount of GLUT-2 messenger RNA were profoundly reduced. Whenever fewer than 60% of beta cells were GLUT-2-positive, the response to glucose was absent and hyperglycemia exceeded 11 mM plasma glucose. We conclude that in NIDDM underexpression of GLUT-2 messenger RNA lowers high Km glucose transport in beta cells, and thereby impairs glucose-stimulated insulin secretion and prevents correction of hyperglycemia.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 26, 1990

Volume

250

Issue

4980

Start / End Page

546 / 549

Location

United States

Related Subject Headings

  • Rats, Zucker
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Obesity
  • Monosaccharide Transport Proteins
  • Methylglucosides
  • Male
  • Kinetics
  • Islets of Langerhans
 

Citation

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ICMJE
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Johnson, J. H., Ogawa, A., Chen, L., Orci, L., Newgard, C. B., Alam, T., & Unger, R. H. (1990). Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science, 250(4980), 546–549. https://doi.org/10.1126/science.2237405
Johnson, J. H., A. Ogawa, L. Chen, L. Orci, C. B. Newgard, T. Alam, and R. H. Unger. “Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.Science 250, no. 4980 (October 26, 1990): 546–49. https://doi.org/10.1126/science.2237405.
Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, Alam T, et al. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science. 1990 Oct 26;250(4980):546–9.
Johnson, J. H., et al. “Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.Science, vol. 250, no. 4980, Oct. 1990, pp. 546–49. Pubmed, doi:10.1126/science.2237405.
Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, Alam T, Unger RH. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science. 1990 Oct 26;250(4980):546–549.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

October 26, 1990

Volume

250

Issue

4980

Start / End Page

546 / 549

Location

United States

Related Subject Headings

  • Rats, Zucker
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Obesity
  • Monosaccharide Transport Proteins
  • Methylglucosides
  • Male
  • Kinetics
  • Islets of Langerhans