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Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific.

Publication ,  Journal Article
Astles, JR; Sedor, FA; Toffaletti, JG
Published in: Clin Biochem
February 1996

OBJECTIVES: To insure commutability (equivalence) between whole blood and plasma glucose values and to assess potential interferences in glucose oxidase methods. DESIGN AND METHODS: We compared plasma glucose results by the Ektachem 700 analyzer to glucose results on whole blood by the Nova Stat Profile 6, and by the YSI 2300, both without hematocrit correction (YSIunc) and with two different hematocrit (Hct) corrections. The two correction methods were: (a) whole blood results multiplied by 1.11 (YSI1.11), and (b) whole blood results corrected for Hct with the programmed YSI algorithm (YSIcor). Several compounds were tested for interference. RESULTS: 88% of YSIcor results agreed with plasma results within plus/minus 5%, and 78% of Nova and 74% of YSI1.11 results were within this limit. YSIcor results were unaffected by Hct and were valid even when erythrocyte size was abnormal. At low Hct, Nova results were falsely decreased, while YSI1.11 results were falsely elevated. The Ektachem was most affected by ascorbic acid, and the Nova was especially affected by acetaminophen. CONCLUSIONS: The YSI algorithm-corrected whole blood glucose results were commutable with plasma results and the YSI was unaffected by the compounds tested, including acetaminophen and acetylsalicylic acid.

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Published In

Clin Biochem

DOI

ISSN

0009-9120

Publication Date

February 1996

Volume

29

Issue

1

Start / End Page

27 / 31

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Plasma
  • Linear Models
  • Humans
  • Hematocrit
  • Glucose Oxidase
  • General Clinical Medicine
  • Evaluation Studies as Topic
  • Erythrocyte Indices
 

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Astles, J. R., Sedor, F. A., & Toffaletti, J. G. (1996). Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific. Clin Biochem, 29(1), 27–31. https://doi.org/10.1016/0009-9120(95)02010-1
Astles, J. R., F. A. Sedor, and J. G. Toffaletti. “Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific.Clin Biochem 29, no. 1 (February 1996): 27–31. https://doi.org/10.1016/0009-9120(95)02010-1.
Astles JR, Sedor FA, Toffaletti JG. Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific. Clin Biochem. 1996 Feb;29(1):27–31.
Astles, J. R., et al. “Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific.Clin Biochem, vol. 29, no. 1, Feb. 1996, pp. 27–31. Pubmed, doi:10.1016/0009-9120(95)02010-1.
Astles JR, Sedor FA, Toffaletti JG. Evaluation of the YSI 2300 glucose analyzer: algorithm-corrected results are accurate and specific. Clin Biochem. 1996 Feb;29(1):27–31.
Journal cover image

Published In

Clin Biochem

DOI

ISSN

0009-9120

Publication Date

February 1996

Volume

29

Issue

1

Start / End Page

27 / 31

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Plasma
  • Linear Models
  • Humans
  • Hematocrit
  • Glucose Oxidase
  • General Clinical Medicine
  • Evaluation Studies as Topic
  • Erythrocyte Indices