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Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats.

Publication ,  Journal Article
Thet, LA; Parra, SC; Shelburne, JD
Published in: Exp Lung Res
1986

We studied changes in lung ultrastructure and collagen content during the repair of acute lung injury in adult rats exposed to 100% O2 for 60 h and recovering in ambient air. In the interstitium, during the first 3 days of repair, the number of neutrophils decreased 16-fold, and monocytes and lymphocytes increased to 7-fold and 4-fold the respective control values. Myofibroblasts increased about 5-fold and the volume of the interstitial matrix remained high. By 7 days, the differential count of inflammatory cells was normal although the number of total interstitial cells and myofibroblasts decreased more slowly. In the capillary endothelium, after 3 days of repair, the cells were hypertrophied and had organelle-rich cytoplasm, and total cell number had increased back to control values; endothelial cell number increased an additional 63% between 3 and 7 days of repair. In the epithelium, type 2 cells increased 150% during the first 3 days of repair before decreasing; type 1 cell number did not change. After 28 days of repair, the lungs appeared qualitatively almost normal; however, interstitial cell number and collagen content were still increased. We conclude that the repair of oxygen-induced lung injury involves a complex pattern of morphologic changes that has important similarities to those occurring during repair on other tissues such as the skin.

Duke Scholars

Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

1986

Volume

11

Issue

3

Start / End Page

209 / 228

Location

England

Related Subject Headings

  • Time Factors
  • Respiratory System
  • Rats, Inbred Strains
  • Rats
  • Oxygen
  • Microscopy, Electron
  • Male
  • Lung
  • Epithelium
  • Epithelial Cells
 

Citation

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ICMJE
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Thet, L. A., Parra, S. C., & Shelburne, J. D. (1986). Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats. Exp Lung Res, 11(3), 209–228. https://doi.org/10.3109/01902148609064297
Thet, L. A., S. C. Parra, and J. D. Shelburne. “Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats.Exp Lung Res 11, no. 3 (1986): 209–28. https://doi.org/10.3109/01902148609064297.
Thet, L. A., et al. “Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats.Exp Lung Res, vol. 11, no. 3, 1986, pp. 209–28. Pubmed, doi:10.3109/01902148609064297.
Journal cover image

Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

1986

Volume

11

Issue

3

Start / End Page

209 / 228

Location

England

Related Subject Headings

  • Time Factors
  • Respiratory System
  • Rats, Inbred Strains
  • Rats
  • Oxygen
  • Microscopy, Electron
  • Male
  • Lung
  • Epithelium
  • Epithelial Cells