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Primary malignant fibrous histiocytoma of the lung. A clinicopathologic and ultrastructural study of five cases.

Publication ,  Journal Article
Lee, JT; Shelburne, JD; Linder, J
Published in: Cancer
March 1, 1984

Primary sarcomas of the lung are rare malignant neoplasms which have usually been classified as fibrosarcomas or as leiomyosarcomas. Only five cases of primary malignant fibrous histiocytoma (MFH) of the lung have previously been reported in the literature. The authors reviewed 10 cases of primary pulmonary sarcoma of the lung seen at their institution during the last 12 years, and five of these cases met the morphologic criteria for the diagnosis of MFH. The morphology in these cases is identical to MFH of other body locations, and shows a combination of fibroblast-like and histiocyte-like cells at both the light and electron microscopic level. By electron microscopic examination there was no evidence for anaplastic carcinoma, rhabdomyosarcoma, or leiomyosarcoma. Of the three patients with adequate follow-up, one patient is alive without evidence of disease at 10 years, one died at 5 years without evidence of recurrent sarcoma, and one died at 7 months with liver metastasis. Two other patients are alive without recurrence at 8 months and 1 year, respectively, following surgery. Because MFH is primarily a tumor of the soft tissues of the extremities, patients with MFH of the lung must be carefully evaluated to rule out a metastatic origin. The reported prognosis in patients with primary MFH of the lung is poor, but early surgical resection does offer the possibility of a cure.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 1, 1984

Volume

53

Issue

5

Start / End Page

1124 / 1130

Location

United States

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mitotic Index
  • Middle Aged
  • Microscopy, Electron
  • Male
  • Lysosomes
  • Lymphatic Metastasis
 

Citation

APA
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ICMJE
MLA
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Lee, J. T., Shelburne, J. D., & Linder, J. (1984). Primary malignant fibrous histiocytoma of the lung. A clinicopathologic and ultrastructural study of five cases. Cancer, 53(5), 1124–1130. https://doi.org/10.1002/1097-0142(19840301)53:5<1124::aid-cncr2820530518>3.0.co;2-v
Lee, J. T., J. D. Shelburne, and J. Linder. “Primary malignant fibrous histiocytoma of the lung. A clinicopathologic and ultrastructural study of five cases.Cancer 53, no. 5 (March 1, 1984): 1124–30. https://doi.org/10.1002/1097-0142(19840301)53:5<1124::aid-cncr2820530518>3.0.co;2-v.
Lee, J. T., et al. “Primary malignant fibrous histiocytoma of the lung. A clinicopathologic and ultrastructural study of five cases.Cancer, vol. 53, no. 5, Mar. 1984, pp. 1124–30. Pubmed, doi:10.1002/1097-0142(19840301)53:5<1124::aid-cncr2820530518>3.0.co;2-v.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 1, 1984

Volume

53

Issue

5

Start / End Page

1124 / 1130

Location

United States

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mitotic Index
  • Middle Aged
  • Microscopy, Electron
  • Male
  • Lysosomes
  • Lymphatic Metastasis